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2 results on '"Rossana G Iannitti"'

1. Small Molecule CCR4 Antagonists Protect Mice from Aspergillus Infection and Allergy

Author

Claudio Costantini, Marilena Pariano, Rossana G. Iannitti, Luigina Romani, Silvia Bozza, Giorgia Renga, Jagadeesh Bayry, Università degli Studi di Perugia (UNIPG), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Gestionnaire, HAL Sorbonne Université 5, Cibler la voie IL-3 pour inhiber la fonction basophile en conditions inflammatoires - - BASIN2019 - ANR-19-CE17-0021 - AAPG2019 - VALID, Università degli Studi di Perugia = University of Perugia (UNIPG), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), and ANR-19-CE17-0021,BASIN,Cibler la voie IL-3 pour inhiber la fonction basophile en conditions inflammatoires(2019)

Subjects
0301 basic medicine, Chemokine, CCR4, lcsh:QR1-502, Aspergillosis, Biochemistry, Cystic fibrosis, lcsh:Microbiology, Aspergillus fumigatus, cystic fibrosis, 03 medical and health sciences, Chemokine receptor, 0302 clinical medicine, Immune system, vaccine, medicine, allergic bronchopulmonary aspergillosis, Molecular Biology, invasive aspergillosis, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, biology, business.industry, medicine.disease, biology.organism_classification, 3. Good health, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, biology.protein, Allergic bronchopulmonary aspergillosis, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; The ability to regulate the recruitment of immune cells makes chemokines and their receptors attractive drug targets in many inflammatory diseases. Based on its preferential expression on T helper type 2 (Th2) cells, CC chemokine receptor type 4 (CCR4) has been widely studied in the context of allergic diseases, but recent evidence on the expression of CCR4 in other cell types has considerably expanded the potential applications of CCR4 antagonism. However, the current number of approved indications, as well as the portfolio of CCR4-targeting drugs, are still limited. In the present study, we have assessed the potential therapeutic efficacy of a CCR4 small molecule antagonist, SP50, discovered via an in silico-based approach, against a variety of pre-clinical settings of infection with the fungus Aspergillus fumigatus. We show that SP50 efficiently worked as prophylactic vaccine adjuvant in immunocompetent mice, protected against invasive aspergillosis in immunosuppressed mice. Further, the CCR4 antagonist prevented allergic bronchopulmonary aspergillosis in susceptible mice, and in a murine model of cystic fibrosis, a genetic disorder characterized by chronic pulmonary inflammation and recurrent infections. In conclusion, our results extend the potential applications of CCR4 antagonism and prompt for the development of novel compounds with the potential to progress to clinical trials.

Published
2021
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2. Aryl hydrocarbon receptor control of a disease tolerance defence pathway

Author

Danilo Piobbico, Rossana G. Iannitti, David Gilot, Michael Platten, Maria Teresa Pallotta, Maria Laura Belladonna, Luciana Tissi, Hiroshi Funakoshi, Roberta Bianchi, Toshikazu Nakamura, Alban Bessede, Michel Geffard, Giuseppe Servillo, Claudia Volpi, Cinzia Brunacci, Marco Gargaro, Francesca Fallarino, Matteo Pirro, Paolo Puccetti, Bernard Veyret, Antonio Macchiarulo, George C. Prendergast, Silvio Bicciato, Ciriana Orabona, Gilles J. Guillemin, Richard P. Metz, Carmine Vacca, James B. DuHadaway, Louis Boon, Alfonso Iorio, Tobias V. Lanz, Michael S. Denison, Davide Matino, Emilia Maria Cristina Mazza, Maria Agnese Della Fazia, Luigina Romani, Ursula Grohmann, Teresa Zelante, Laboratoire de l'intégration, du matériau au système (IMS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Departamento de Física Aplicada, Universidade de Vigo, Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Université Sciences et Technologies - Bordeaux 1, Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Lipopolysaccharides, Lipopolysaccharide, Systemic inflammation, IDO, chemistry.chemical_compound, Mice, Receptors, INFECTION, Phosphorylation, Indoleamine 2,3-dioxygenase, Receptor, Kynurenine, INDOLEAMINE 2, AH RECEPTOR, ComputingMilieux_MISCELLANEOUS, Disease Resistance, Regulation of gene expression, Multidisciplinary, biology, tolerance, aryl hydrocarbon receptor (AhR), defence response, Bacterial Infections, TRYPTOPHAN CATABOLISM, Tryptophan Oxygenase, 3. Good health, src-Family Kinases, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Aryl Hydrocarbon, LIGAND-BINDING, [SDV.IMM]Life Sciences [q-bio]/Immunology, medicine.symptom, Signal transduction, Signal Transduction, General Science & Technology, Inflammation, Indoleamine-Pyrrole 2, REGULATORY T-CELLS, INDOLEAMINE 2,3-DIOXYGENASE, DENDRITIC CELLS, ENDOTOXIN TOLERANCE, KYNURENINE, MD Multidisciplinary, medicine, Animals, Indoleamine-Pyrrole 2,3,-Dioxygenase, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, 3-DIOXYGENASE, Aryl hydrocarbon receptor, Endotoxemia, Toll-like receptors, Enzyme Activation, chemistry, Receptors, Aryl Hydrocarbon, Gene Expression Regulation, Dioxygenase, Immunology, biology.protein
Abstract

Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (endotoxin tolerance). We found that a first exposure of mice to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR) and the hepatic enzyme tryptophan 2,3-dioxygenase, which provided an activating ligand to the former, to downregulate early inflammatory gene expression. However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1). AhR-complex-associated Src kinase activity promoted IDO1 phosphorylation and signalling ability. The resulting endotoxin-tolerant state was found to protect mice against immunopathology in Gram-negative and Gram-positive infections, pointing to a role for AhR in contributing to host fitness. © 2014 Macmillan Publishers Limited. All rights reserved.

Published
2014
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