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16 pages, 1 figure, 2 tables, Measuring plankton and associated variables as part of ocean time-series stations has the potential to revolutionize our understanding of ocean biology and ecology and their ties to ocean biogeochemistry. It will open temporal scales (e.g., resolving diel cycles) not typically sampled as a function of depth. In this review we motivate the addition of biological measurements to time-series sites by detailing science questions they could help address, reviewing existing technology that could be deployed, and providing examples of time-series sites already deploying some of those technologies. We consider here the opportunities that exist through global coordination within the OceanSITES network for long-term (climate) time series station in the open ocean. Especially with respect to data management, global solutions are needed as these are critical to maximize the utility of such data. We conclude by providing recommendations for an implementation plan, This work was partially supported from funding to SCOR WG 154 (P-OBS) provided by national committees of the Scientific Committee on Oceanic Research (SCOR) and from a grant to SCOR from the U.S. National Science Foundation (OCE-1840868). FM-K acknowledges the support provided for participation by the Marine Biodiversity Observation Network (MBON) sponsored by NASA, NOAA, ONR, BOEM. HS acknowledges support from the Simons Foundation, With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)