1. Phosphonolipids as non-viral vectors for gene therapy
- Author
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Jean-Jacques Yaouanc, J.‐C. Clement, Herve Des Abbayes, Christine Gable-Guillaume, Gwénaëlle Le Bolc’h, Nathalie Le Bris, Claude Ferec, Virginie Floch, Chimie, Electrochimie Moléculaires et Chimie Analytique (CEMCA), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Génétique moléculaire et génétique épidémiologique, and Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Transfer DNA ,Genetic enhancement ,01 natural sciences ,Ammoniums ,Viral vector ,03 medical and health sciences ,chemistry.chemical_compound ,Drug Discovery ,Polyamines ,[CHIM]Chemical Sciences ,Non-vital transfection ,030304 developmental biology ,Pharmacology ,0303 health sciences ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Genetic transfer ,General Medicine ,In vitro ,0104 chemical sciences ,Biochemistry ,Cell culture ,Phosphonolipids ,DNA ,K562 cells - Abstract
International audience; Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoietic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient.
- Published
- 1998
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