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2. Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model

Author

Attoui, Houssam, Monsion, Baptiste, Klonjkowski, Bernard, Zientara, Stéphan, Mertens, Peter, Mohd Jaafar, Fauziah, Virologie UMR1161 (VIRO), École nationale vétérinaire d'Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École nationale vétérinaire - Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Nottingham, UK (UON), and European Project: 727393,H2020,H2020-EU.3.2.1.1.,PALE-Blu(2017)

Subjects
BTV-1, BTV-26, Receptor, Interferon alpha-beta, MESH: Disease Transmission, Infectious, Ceratopogonidae, Serogroup, Microbiology, MESH: Bluetongue virus, Article, Mice, IFNAR(−/−) mice, bluetongue virus, Disease Transmission, Infectious, Animals, MESH: Bluetongue, bluetongue, Mice, Knockout, vector independent transmission, horizontal transmission, QR1-502, MESH: Ceratopogonidae, Disease Models, Animal, MESH: Reassortant Viruses, IFNAR (−/−) mice, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, reassortment, Genetic Engineering, Reassortant Viruses, BTV
Abstract

Bluetongue virus serotypes 1 to 24 are transmitted primarily by infected Culicoides midges, in which they also replicate. However, “atypical” BTV serotypes (BTV-25, -26, -27 and -28) have recently been identified that do not infect and replicate in adult Culicoides, or a Culicoides derived cell line (KC cells). These atypical viruses are transmitted horizontally by direct contact between infected and susceptible hosts (primarily small ruminants) causing only mild clinical signs, although the exact transmission mechanisms involved have yet to be determined. We used reverse genetics to generate a strain of BTV-1 (BTV-1 RGC7) which is less virulent, infecting IFNAR(−/−) mice without killing them. Reassortant viruses were also engineered, using the BTV-1 RGC7 genetic backbone, containing individual genome segments derived from BTV-26. These reassortant viruses were used to explore the genetic control of horizontal transmission (HT) in the IFNAR(−/−) mouse model. Previous studies showed that genome segments 1, 2 and 3 restrict infection of Culicoides cells, along with a minor role for segment 7. The current study demonstrates that genome segments 2, 5 and 10 of BTV-26 (coding for proteins VP2, NS1 and NS3/NS3a/NS5, respectively) are individually sufficient to promote HT.

Published
2021

3. [Eradication of foot-and-mouth disease in France]

Author

Zientara, Stéphan, Bakkali-Kassimi, Labib, and Blaise-Boisseau, Sandra

Subjects
[SDV] Life Sciences [q-bio], Foot-and-Mouth Disease
Abstract

Eradication of foot-and-mouth disease in France Foot-and-mouth disease (FMD) is a highly contagious viral disease that affects domestic and wild artiodactyls (mainly cattle, sheep, goats, pigs, camelids and deer). Before the 1980s, Europe, and in particular France, regularly experienced FMD epizootics with a very high number of outbreaks. A compulsory vaccination policy has been implemented at European level. Thus, every year, the French population of domestic cattle (about 20 million animals) was vaccinated. In 1991, due to the lack of detection of the circulating virus, vaccination was stopped. Since that date, France has become a country free from foot-and-mouth disease. The fight against this disease is a good example of the efficacy of vaccination to eradicate Foot-and-mouth disease virus.

Published
2021

11. Real-Time monitoring of Equid alphaherpesviruses infectivity in equine dermal cell based on impedance measurements: effects of aciclovir and ganciclovir treatments

Author

Thieulent, Côme, Hue, Erika, Fortier, Christine, Suzanne, Peggy, Zientara, Stéphan, Munier-Lehmann, Hélène, Hans, Aymeric, Pitel, Pierre-Hugues, Vidalain, Pierre-Olivier, Pronost, Stéphane, LABÉO, Pôle d’analyses et de recherche de Normandie (LABÉO), Biologie, génétique et thérapies ostéoarticulaires et respiratoires (BIOTARGEN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), ImpedanCELL, Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Chimie et Biocatalyse, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Laboratoire de pathologie équine de Dozulé, Génomique Virale et Vaccination, Génomique virale et vaccination, Virologie UMR1161 (VIRO), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Interactions Cellules Organismes Environnement (ICORE), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-CHU Caen, Normandie Université (NU), Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-École nationale vétérinaire d'Alfort (ENVA), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de la Recherche Agronomique (INRA)-École nationale vétérinaire d'Alfort (ENVA), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie, and Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)

Subjects
viruses, [SDV]Life Sciences [q-bio], [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Five herpesvirus have been reported to infect horses and 3 belong to the Alphaherpesvirinae subfamily (equine herpesvirus-1, EHV-4 and EHV-3). Among them, EHV-1 is the most pathogenic and causes respiratory disease in young horses, abortion in mares, neonatal death and neurologic damages, also call equine herpesvirus myeloencephalopathy. EHV-4, also named the rhinopneumonia virus, is closely related to EHV-1 but mostly causes respiratory disease and only sporadic abortion and neonatal infection in horses. EHV-3 is distinct from previous viruses and is responsible for equine coital exanthema, characterized by formation of papules, pustules, ulcers and vesicles on the external genitalia of horses. The equine industry economical loss linked to EHV infection is significant, which warrants surveillance and prophylaxis. Currently, no antiviral molecule has a marketing authorization for equine species despite critically needs, warranting the development or adaptation of drugs that are effective against equine viruses.The aims of this work were 1) to investigate the efficacy of Real-Time Cell Analysis (RTCA) system to monitor EHV infections in equine dermal cells 2) to assess the effectiveness of acyclovir (ACV) and ganciclovir (GCV) against EHV-1, EHV-4 and EHV-3 by RTCA system and 3) to investigate the capacity of RTCA system for the screening of compounds library in order to identified new inhibitors of these viruses. To confirm results achieved, monitoring of cell morphology by microscopy and quantification of viral loads were perform in parallel.Antiviral effect of ACV or GCV against the EHV-1 KyD strain was evaluated by RTCA. Results showed that ACV and GCV prevented the impedance decrease induced by EHV-1 infection in a dose-dependent manner and EC50 measured were 9.88 ± 2.14 µg/ml and 0.62 ± 0.49 µg/ml, respectively. The ACV and GCV EC50 against EHV-4 were 17.38 ± 5.95 µg/ml and 2.79 ± 0.25 µg/ml, respectively. Against EHV-3, the ACV and GCV EC50 were 15.23 ± 2.85 µg/ml and 1.86 ± 0.46 µg/ml, respectively. All the data were confirm by qPCR and microscopy observation. The screening of compounds library allowed identifying several molecules with an antiviral activity needing further investigation.This study confirms the efficiency of RTCA to monitor cytopathic effect formation induced by equine alphaherpesviruses on E. Derm cells in real-time. In this model, GCV was shown to be the most effective against all viruses used to infect E. Derm cells. This technology aims to complement and support conventional methods used in the field of virology.

Published
2018

12. Real-Time monitoring of Equid alphaherpesviruses infectivity in equine dermal cell based on impedance measurements: effects of aciclovir and ganciclovir treatments (poster)

Author

Thieulent, Côme, Hue, Erika, Fortier, Christine, Suzanne, Peggy, Zientara, Stéphan, Munier-Lehmann, Hélène, Hans, Aymeric, Pitel, Pierre-Hugues, Vidalain, Pierre-Olivier, Pronost, Stéphane, LABÉO, Pôle d’analyses et de recherche de Normandie (LABÉO), Biologie, génétique et thérapies ostéoarticulaires et respiratoires (BIOTARGEN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), ImpedanCELL, Interactions Cellules Organismes Environnement (ICORE), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-CHU Caen, Normandie Université (NU), Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Virologie UMR1161 (VIRO), Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-École nationale vétérinaire d'Alfort (ENVA), Chimie et Biocatalyse, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Laboratoire de pathologie équine de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie, and Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)

Subjects
viruses, [SDV]Life Sciences [q-bio], [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology
Abstract

International audience; Five herpesvirus have been reported to infect horses and 3 belong to the Alphaherpesvirinae subfamily (equine herpesvirus-1, EHV-4 and EHV-3). Among them, EHV-1 is the most pathogenic and causes respiratory disease in young horses, abortion in mares, neonatal death and neurologic damages, also call equine herpesvirus myeloencephalopathy. EHV-4, also named the rhinopneumonia virus, is closely related to EHV-1 but mostly causes respiratory disease and only sporadic abortion and neonatal infection in horses. EHV-3 is distinct from previous viruses and is responsible for equine coital exanthema, characterized by formation of papules, pustules, ulcers and vesicles on the external genitalia of horses. The equine industry economical loss linked to EHV infection is significant, which warrants surveillance and prophylaxis. Currently, no antiviral molecule has a marketing authorization for equine species despite critically needs, warranting the development or adaptation of drugs that are effective against equine viruses.The aims of this work were 1) to investigate the efficacy of Real-Time Cell Analysis (RTCA) system to monitor EHV infections in equine dermal cells 2) to assess the effectiveness of acyclovir (ACV) and ganciclovir (GCV) against EHV-1, EHV-4 and EHV-3 by RTCA system and 3) to investigate the capacity of RTCA system for the screening of compounds library in order to identified new inhibitors of these viruses. To confirm results achieved, monitoring of cell morphology by microscopy and quantification of viral loads were perform in parallel.Antiviral effect of ACV or GCV against the EHV-1 KyD strain was evaluated by RTCA. Results showed that ACV and GCV prevented the impedance decrease induced by EHV-1 infection in a dose-dependent manner and EC50 measured were 9.88 ± 2.14 µg/ml and 0.62 ± 0.49 µg/ml, respectively. The ACV and GCV EC50 against EHV-4 were 17.38 ± 5.95 µg/ml and 2.79 ± 0.25 µg/ml, respectively. Against EHV-3, the ACV and GCV EC50 were 15.23 ± 2.85 µg/ml and 1.86 ± 0.46 µg/ml, respectively. All the data were confirm by qPCR and microscopy observation. The screening of compounds library allowed identifying several molecules with an antiviral activity needing further investigation.This study confirms the efficiency of RTCA to monitor cytopathic effect formation induced by equine alphaherpesviruses on E. Derm cells in real-time. In this model, GCV was shown to be the most effective against all viruses used to infect E. Derm cells. This technology aims to complement and support conventional methods used in the field of virology.

Published
2018

13. Evaluation of the in utero infection caused by SBV on goats

Author

Laloy, Eve, Riou, Mickaël, Pozzi, Nathalie, Breard, Emmanuel, Barc, Celine, Breton, Sylvain, Delaunay, Rémi, Rainbourg, Maxime, Ponsart, Claire, Trapp, Sascha, Zientara, Stéphan, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Plateforme d'Infectiologie Expérimentale (PFIE), Institut National de la Recherche Agronomique (INRA), Laboratoire National de Contrôle des Reproducteurs (LNCR), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), and ProdInra, Migration

Subjects
feotus physiopathology, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], pregnant goats, Schmallenberg virus, seroconversion, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

14. Strong protection induced by an experimental DIVA subunit vaccine against bluetongue virus serotype 8 in cattle

Author

Anderson, Jenna, Hägglund, Sara, Bréard, Emmanuel, Riou, Mickaël, Zohari, Siamak, Comtet, Loic, Olofson, Ann-Sophie, Gélineau, Robert, Martin, Guillaume, Elvander, Marianne, Blomqvist, Gunilla, Zientara, Stéphan, Valarcher, Jean Francois, Swedish University of Agricultural Sciences (SLU), Virologie UMR1161 (VIRO), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Plateforme d'Infectiologie Expérimentale (PFIE), Institut National de la Recherche Agronomique (INRA), National Veterinary Institute, and IDvet [Grabels]

Subjects
Subunit, Injections, Subcutaneous, viruses, Viral Nonstructural Proteins, DIVA, Antibodies, Viral, Serogroup, Bluetongue, Adjuvants, Immunologic, Immunology and Microbiology(all), Animals, Viremia, Bluetongue virus serotype 8, Phospholipids, Protection, Vaccination, Public Health, Environmental and Occupational Health, virus diseases, Viral Vaccines, Saponins, biochemical phenomena, metabolism, and nutrition, veterinary(all), Antibodies, Neutralizing, Drug Combinations, Infectious Diseases, Cholesterol, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Vaccines, Subunit, Molecular Medicine, Female, Cattle, Vaccine, Bluetongue virus
Abstract

International audience; Bluetongue virus (BTV) infections in ruminants pose a permanent agricultural threat since new serotypes are constantly emerging in new locations. Clinical disease is mainly observed in sheep, but cattle were unusually affected during an outbreak of BTV seroype 8 (BTV-8) in Europe. We previously developed an experimental vaccine based on recombinant viral protein 2 (VP2) of BTV-8 and non-structural proteins 1 (NS1) and NS2 of BTV-2, mixed with an immunostimulating complex (ISCOM)-matrix adjuvant. We demonstrated that bovine immune responses induced by this vaccine were as good or superior to those induced by a classic commercial inactivated vaccine. In this study, we evaluated the protective efficacy of the experimental vaccine in cattle and, based on the detection of VP7 antibodies, assessed its DIVA compliancy following virus challenge. Two groups of BTV-seronegative calves were subcutaneously immunized twice at a 3-week interval with the subunit vaccine (n=6) or with adjuvant alone (n=6). Following BTV-8 challenge 3 weeks after second immunization, controls developed viremia and fever associated with other mild clinical signs of bluetongue disease, whereas vaccinated animals were clinically and virologically protected. The vaccine-induced protection was likely mediated by high virus-neutralizing antibody titers directed against VP2 and perhaps by cellular responses to NS1 and NS2. T lymphocyte responses were cross-reactive between BTV-2 and BTV-8, suggesting that NS1 and NS2 may provide the basis of an adaptable vaccine that can be varied by using VP2 of different serotypes. The detection of different levels of VP7 antibodies in vaccinated animals and controls after challenge suggested a compliancy between the vaccine and the DIVA companion test. This BTV subunit vaccine is a promising candidate that should be further evaluated and developed to protect against different serotypes.

Published
2014

15. Epidémiologie comparée des orbivirus en Guadeloupe et à la Réunion

Author

Gerbier, Guillaume, Sailleau, Corinne, Breard, Emmanuel, Viarouge, Cyril, Desprat, Alexandra, Lasne, Laurent, Gouyet, Loïc, Desvars, Amélie, Baldet, Thierry, Biteau, Fabienne, Delecolle, Jean Claude, Garros, Claire, Roger, François, Zientara, Stéphan, Direction Régionale de l'Agriculture, de l'Alimentation et de la Forêt de Guadeloupe, Partenaires INRAE, Virologie UMR1161 (VIRO), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Direction de l'Alimentation, de l'Agriculture et de la Fôret de la Réunion, Direction de l'Alimentation, de l'Agriculture et de la Fôret de Martinique (DAAF Martinique), Contrôle des maladies animales exotiques et émergentes (UMR CMAEE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Direction de l'Alimentation, de l'Agriculture et de la Fôret de Mayotte (DAAF Mayotte), Université de Strasbourg (UNISTRA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), and Institut National de la Recherche Agronomique (INRA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-École nationale vétérinaire d'Alfort (ENVA)

Subjects
Réunion, Ruminant, DOM-TOM, [SDV]Life Sciences [q-bio], Orbivirus,DOM-TOM, Réunion, Guadeloupe, épidémiologie, Culicoides, L73 - Maladies des animaux, Sérotype, épidémiologie, Fièvre catarrhale du mouton, Orbivirus, Guadeloupe, ComputingMilieux_MISCELLANEOUS
Abstract

La Guadeloupe et la Réunion sont deux départements d'Outre-mer dans lesquels la fièvre catarrhale ovine est enzootique. Depuis 2010, il a été démontré qu'une autre arbovirose transmise par des Culicoides, la maladie épizootique hémorragique des cervidés est aussi présente dans ces îles. Cet article présente les particularités de l'épidémiologie de ces maladies en distinguant les quatre déterminants principaux de l'épidémiologie des maladies vectorielles : animaux/environnement/espèces vectrices de Culicoides/virus. Ces comparaisons montrent la pertinence de la notion de "pathosystème" qui illustre les différences observées pour une même maladie dans des contextes épidémiologiques différents.

Published
2011

16. Bluetongue control in Europe - New challenges and achievements Abstracts

Author

Makoschey, B, Maclachlan, J, von Der Wuijckhuise, L, Kirschvink, N, Dal Pozzo, Fabiana, Petit, H, Kaandorp-Huber, C, von Der Rijn, P, Sellal, E, Oura, C, Boinas, F, Cavirani, S, de Clercq, K, Lucientes, J, Meijjes, Cp, Zientara, Stéphan, Meyer, Gilles, Thiry, E, Inconnu, Virologie, École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence Française de Sécurité Sanitaire des Aliments (AFSSA), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009

17. Le virus myxomateux vecteur vaccinal : application à la vaccination contre la bluetongue

Author

Pignolet, Beatrice, Albina, Emmanuel, Zientara, Stéphan, Gelfi, Jacqueline, Inconnu, Virologie, École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence Française de Sécurité Sanitaire des Aliments (AFSSA), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2006

18. Bluetongue control using vaccines : experience of the Mediterranean islands

Author

Gerbier, Guillaume, Hendrikx, Pascal, FRANCOIS ROGER, Zientara, Stéphan, Biteau-Coroller, Fabienne, Grillet, Colette, Baldet, Thierry, Albina, Emmanuel, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Ministère de l'agriculture et de la pêche, Virologie, École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Agence Française de Sécurité Sanitaire des Aliments (AFSSA), and Agence Française de Sécurité Sanitaire des Aliments

Subjects
BLUETONGUE, MEDITERRANEAN, VACCINATION, VACCINE, vaccin, [SDV]Life Sciences [q-bio], L73 - Maladies des animaux, Virus, ovin, Immunologie, corse, Fièvre catarrhale du mouton
Abstract

International audience; Following the emergence of bluetongue (BT) virus serotype 2 on the island of Corsica in 2000, annual monovalent vaccination campaigns of the ovine population were conducted between 2001 and 2003. Despite vaccination, outbreaks were reported from several areas in 2001, but since November 2001, the absence of clinical cases in Corsica proves that vaccination is effective. This experience in Corsica is examined and, using available data, compared to the situation and the vaccination strategies on other Mediterranean islands. In light of the expansion of a new serotype of BTV onto these islands, a Mediterranean information network for BT and other emerging diseases is proposed.

Published
2003

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