1. Guidance on allergenicity assessment of genetically modified plants
- Author
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EFSA Panel on Genetically Modified Organisms (GMO), Hanspeter Naegeli, Andrew Nicholas Birch, Josep Casacuberta, Adinda De Schrijver, Mikolaj Antoni Gralak, Philippe Guerche, Huw Jones, Barbara Manachini, Antoine Messéan, Elsa Ebbesen Nielsen, Fabien Nogué, Christophe Robaglia, Nils Rostoks, Jeremy Sweet, Christoph Tebbe, Francesco Visioli, Jean‐Michel Wal, Philippe Eigenmann, Michelle Epstein, Karin Hoffmann‐Sommergruber, Frits Koning, Martinus Lovik, Clare Mills, Francisco Javier Moreno, Henk van Loveren, Regina Selb, Antonio Fernandez Dumont, Institut Jean-Pierre Bourgin (IJPB), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Naegeli, H., Birch, A., Casacuberta, J., De Schrijver, A., Gralak, M., Guerche, P., Jones, H., Manachini, B., Messéan, A., Nielsen, E., Nogué, F., Robaglia, C., Rostoks, N., Sweet, J., Tebbe, C., Visioli, F., Wal, J., Eigenmann, P., Epstein, M., Hoffmann‐sommergruber, K., Koning, F., Lovik, M., Mills, C., Moreno, F., van Loveren, H., Selb, R., Fernandez Dumont, A., and University of Zurich
- Subjects
allergenicity assessment ,Veterinary (miscellaneous) ,[SDV]Life Sciences [q-bio] ,newly expressed proteins ,Plant Science ,Genetically modified crops ,TP1-1185 ,010501 environmental sciences ,Biology ,01 natural sciences ,Microbiology ,Biosafety ,0404 agricultural biotechnology ,Protein digestibility ,guidance ,endogenous allergenicity ,GMO ,TX341-641 ,0105 earth and related environmental sciences ,2. Zero hunger ,business.industry ,Nutrition. Foods and food supply ,Chemical technology ,10079 Institute of Veterinary Pharmacology and Toxicology ,04 agricultural and veterinary sciences ,Food safety ,040401 food science ,3. Good health ,Biotechnology ,Scientific Opinion ,Settore AGR/11 - Entomologia Generale E Applicata ,570 Life sciences ,biology ,newly expressed protein ,Animal Science and Zoology ,Parasitology ,Immune reaction ,business ,Risk assessment ,Food Science - Abstract
This document provides supplementary guidance on specific topics for the allergenicity risk assessment of genetically modified plants. In particular, it supplements general recommendations outlined in previous EFSA GMO Panel guidelines and Implementing Regulation (EU) No 503/2013. The topics addressed are non‐IgE‐mediated adverse immune reactions to foods, in vitro protein digestibility tests and endogenous allergenicity. New scientific and regulatory developments regarding these three topics are described in this document. Considerations on the practical implementation of those developments in the risk assessment of genetically modified plants are discussed and recommended, where appropriate., This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2017.EN-1259/full
- Published
- 2017
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