1. Phenytoin-carbamazepine cross-sensitivity.
- Author
-
Reents SB, Luginbuhl WE, and Davis SM
- Subjects
- Adult, Blood Cell Count, Cross Reactions, Female, Humans, Liver Function Tests, Carbamazepine adverse effects, Drug Hypersensitivity physiopathology, Phenytoin adverse effects
- Abstract
A case of phenytoin-carbamazepine cross-sensitivity is presented. Similar signs and symptoms occurred during administration of both drugs. A common metabolic intermediate is offered as a possible explanation of the mechanism. Clinicians should be careful when choosing alternatives in patients with hypersensitivity reactions to anticonvulsants. Valproic acid may be the safest choice in this setting.
- Published
- 1989
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