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Different plant-derived bioactive compounds have the potential to be used for medical applications. One of the native medicinal shrub plant species in the Mediterranean area is Micromeria fruticosa from the Lamiaceae family. In the present work, the antioxidant activity, antimicrobial activity, phytochemical screening analysis, total phenolic content (TPC) and total flavonoid content (TFC) were determined for plant extracts of M. fruticosa collected from Jordan. Furthermore, the identification of phenolic compounds was done using liquid chromatography. Results showed that strong antioxidant activity (93.54%) was obtained from butanol extract while water extract exhibited the weakest antioxidant activity (13.7%). The essential oil extract showed the most potent activities against different types of bacteria compared to butanol and aqueous methanol extracts, with minimum inhibitory concentration (MIC) values of 0.2–0.75 mg/ml. The phytochemical analysis of M. fruticosa showed the presence of flavonoid, alkaloids, phenols, and tannins in all solvents extract, with maximal phytochemical compounds obtained from butanol extract. The highest TPC, TFC values were measured butanol extract of M. fruticosa, whereas the lowest values were measured for water extract. The ions chromatographic analyses (RP-HPLC) for phenolic compounds present in extracts fraction revealed that the most abundant phenolic acids were gallic acid and ellagic acid. Results indicate that M. fruticosa extracts may be used in drug industry as a source of effective compounds. [ABSTRACT FROM AUTHOR]