11 results on '"Mruthyunjaya, P"'
Search Results
2. Intraoperative Complications With Vitreous Biopsy for Molecular Proteomics.
- Author
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Mishra K, Velez G, Chemudupati T, Tang PH, Mruthyunjaya P, Sanislo SR, and Mahajan VB
- Subjects
- Humans, Retrospective Studies, Proteomics, Postoperative Complications surgery, Vitrectomy adverse effects, Vitrectomy methods, Intraoperative Complications, Biopsy adverse effects, Retinal Detachment surgery
- Abstract
Objective: To study the incidence of intraoperative complications while collecting a vitreous sample for proteomic biomarker analyses during small-gauge pars plana vitrectomy (PPV)., Methods: A retrospective case series was assembled from the surgical logs and charts of patients who underwent 23-, 25-, and 27-gauge PPV along with an undiluted vitreous biopsy. Primary surgical indication and detailed operative reports were reviewed. Complications specific to vitreous biopsy were assessed while complications related to vitrectomy in general without biopsy were not tabulated., Results: In 1190 eyes that underwent vitreous biopsy, the most common indications for PPV were rhegmatogenous retinal detachment (24.2%), epiretinal membrane (ERM) (21.7%), vitreous hemorrhage (11.0%), uveitis (8.3%), and macular hole (7.5%). An adequate sample of 0.5 cc to 1.0 cc was obtained in all cases. There was one sclerotomy break associated with biopsy, but no instances of lens touch, retinal contusion, retinal detachment, or intraocular hemorrhage., Conclusions: Undiluted vitreous biopsy obtained at the time of small-gauge vitrectomy is a generally safe procedure and may be considered for collection of samples for proteomic analysis. [ Ophthalmic Surg Lasers Imaging Retina 2023;54:32-36.] .
- Published
- 2023
- Full Text
- View/download PDF
3. Vitreofoveal Traction Associated With Pilocarpine for Presbyopia.
- Author
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Amarikwa L, Michalak SM, Caul S, Mruthyunjaya P, and Rahimy E
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- Female, Humans, Pilocarpine adverse effects, Tomography, Optical Coherence, Traction, Presbyopia, Retinal Diseases diagnosis, Vitreous Detachment diagnosis
- Abstract
Vuity (pilocarpine HCL ophthalmic 1.25%) was approved for the treatment of presbyopia in October 2021. Previous case series have reported the presence of vitreofoveal traction and retinal detachment following pilocarpine administration, but this was not reported in the recent randomized control trials assessing the efficacy of Vuity. The authors report a case of a woman of 65 years who developed vitreomacular traction immediately following the first administration of Vuity, review the literature, and present considerations regarding screening and management of patients starting Vuity. [ Ophthalmic Surg Lasers Imaging Retina 2022; 53:410-411.] .
- Published
- 2022
- Full Text
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4. Anti-Vascular Endothelial Growth Factor Therapy for Radiation Retinopathy.
- Author
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Rayess N and Mruthyunjaya P
- Subjects
- Humans, Intravitreal Injections, Radiation Injuries complications, Radiation Injuries diagnosis, Retina radiation effects, Retinal Diseases diagnosis, Retinal Diseases etiology, Tomography, Optical Coherence methods, Vascular Endothelial Growth Factor A antagonists & inhibitors, Angiogenesis Inhibitors administration & dosage, Radiation Injuries drug therapy, Retina diagnostic imaging, Retinal Diseases drug therapy, Visual Acuity
- Abstract
Background and Objective: The purpose of this article is to review the role of anti-vascular endothelial growth factor (VEGF) therapy in treating patients with radiation retinopathy (RR)., Patients and Methods: RR can be associated with a significant decrease in visual acuity (VA) related to the development of cystoid macular edema, macular ischemia, and proliferative retinopathy leading to neovascular glaucoma., Results: Anti-VEGF therapy is effective at stabilizing VA in around 80% of patients and achieving reductions in central macular thickness when it is administered using a constant algorithm. Furthermore, consistent prophylactic anti-VEGF therapy reduces the risk of development of RR, neovascularization of the iris, and neovascularization glaucoma., Conclusion: Future studies are needed to determine the optimal regimen for anti-VEGF therapy according to patient risk factors and likelihood of developing RR. [Ophthalmic Surg Lasers Imaging Retina. 2020;51:S44-S49.]., (Copyright 2020, SLACK Incorporated.)
- Published
- 2020
- Full Text
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5. Biopsy of a Choroidal Melanoma Using Transvitreal Pars Plana Vitrectomy.
- Author
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Tang PH, Shields RA, Schefler AC, and Mruthyunjaya P
- Subjects
- Humans, Vitreous Body surgery, Biopsy, Fine-Needle methods, Choroid Neoplasms diagnosis, Melanoma diagnosis, Uveal Neoplasms diagnosis, Vitrectomy methods
- Abstract
Determining when a previously benign choroidal nevi becomes malignant can be challenging, as traditional biopsy methods are often invasive and can lead to secondary complications such as endophthalmitis and vitreous hemorrhage. Using a transvitreal approach with the 27-gauge vitrectomy system provides several advantages, including direct visualization, theoretically lower risk of inadvertent seeding, and collection of a larger sample size. In this video, the authors present their technique for transvitreal biopsy of choroidal lesions using the 27-gauge vitreous cutter., (Copyright 2018, SLACK Incorporated.)
- Published
- 2018
- Full Text
- View/download PDF
6. Characterization of Artifacts Associated With Multicolor Confocal Scanning Laser Ophthalmoscopy.
- Author
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Feng HL, Sharma S, Stinnett S, Asrani S, and Mruthyunjaya P
- Subjects
- Fundus Oculi, Humans, Microscopy, Confocal standards, Ophthalmoscopy standards, Retrospective Studies, Tomography, Optical Coherence methods, Artifacts, Microscopy, Confocal methods, Ophthalmoscopy methods, Optic Nerve Diseases diagnostic imaging, Retinal Diseases diagnostic imaging
- Abstract
Background and Objective: To characterize the appearance of three types of artifacts observed on multicolor confocal scanning laser ophthalmoscopy (cSLO)., Patients and Methods: Retrospective review of 159 eyes of 96 consecutive patients from the Duke Eye Center who underwent multicolor cSLO with spectral-domain optical coherence tomography (SD-OCT). Infrared (IR), green, blue, and multicolor reflectance images were evaluated for artifacts with corresponding SD-OCT scans available for reference., Results: Multicolor cSLO artifacts were detected in 23.3% (37 of 159) of eyes and comprised three main patterns: spot, wisp, and net. Only three instances of these artifacts were detected on IR reflectance versus 34, 37, and 35 instances on green, blue, and multicolor reflectance, respectively. Artifacts were observed in 0% of eyes with clear lenses, 27.7% of eyes with cataracts, and in 20.8% of eyes with posterior chamber intraocular lenses., Conclusion: Awareness of spot, wisp, and net artifacts when interpreting multicolor cSLO images may facilitate the identification of true retinal pathology. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:810-815.]., (Copyright 2017, SLACK Incorporated.)
- Published
- 2017
- Full Text
- View/download PDF
7. Outcomes of 27-Gauge Vitrectomy-Assisted Choroidal and Subretinal Biopsy.
- Author
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Grewal DS, Cummings TJ, and Mruthyunjaya P
- Subjects
- Adult, Aged, Aged, 80 and over, Choroid Neoplasms surgery, Diagnosis, Differential, Equipment Design, Female, Follow-Up Studies, Humans, Male, Melanoma surgery, Microsurgery methods, Middle Aged, Reproducibility of Results, Retrospective Studies, Biopsy instrumentation, Choroid pathology, Choroid Neoplasms diagnosis, Melanoma diagnosis, Retina pathology, Vitrectomy instrumentation
- Abstract
Background and Objective: To report the initial experience of 27-gauge vitrectomy-assisted choroidal and subretinal biopsy PATIENTS AND METHODS: Retrospective, interventional case series. Eighteen eyes of 18 patients undergoing 27-gauge vitrectomy-assisted choroidal (n = 16) or subretinal biopsy (n = 2). Clinical and lesion characteristics, cytopathology, histology, gene expression profiling (GEP), visual acuity (VA), complications including vitreous hemorrhage (VH), development of rhegmatogenous retinal detachment (RD), and need for additional surgeries were analyzed., Results: Indications were choroidal melanoma (n = 10), indeterminate choroidal (n = 5), and subretinal lesions (n = 3). Mean lesion height was 3.33 mm ± 1.55 mm (range: 0.80 mm to 6.75 mm) and largest diameter was 8.63 mm ± 4.14 mm (range: 3 mm to 15.5 mm). Mean number of intralesional biopsy passes required was 1.76 ± 0.83 (range: one to four). During a mean follow-up of 7.4 months ± 2.7 months (range: 4 months to 14 months), VA was unchanged (0.5 logMAR ± 0.6 logMAR vs. 0.7 logMAR ± 0.84 logMAR; P = .07). Pathologic diagnosis was obtained in 16 of 18 eyes (88.9%), and GEP data were collected for all 11 choroidal melanomas. Post-biopsy VH occurred in 13 of 18 eyes (72.2%) and was severe enough to require a concurrent limited vitrectomy in six eyes (33.3%). These eyes had a greater lesion height compared to eyes not requiring a vitrectomy (4.08 mm ± 1.68 mm vs. 2.76 mm ± 1.43 mm; P = .04). A rhegmatogenous RD requiring repeat surgery developed in two of 18 eyes (11.1%)., Conclusion: The authors concluded that 27-gauge vitrectomy-assisted choroidal and subretinal biopsy established a diagnosis in 88.9% of eyes in lesions 0.8 mm or larger. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:406-415.]., (Copyright 2017, SLACK Incorporated.)
- Published
- 2017
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8. Portable Optical Coherence Tomography Detection or Confirmation of Ophthalmoscopically Invisible or Indeterminate Active Retinoblastoma.
- Author
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Seider MI, Grewal DS, and Mruthyunjaya P
- Subjects
- Diagnosis, Differential, Equipment Design, Female, Humans, Infant, Newborn, Ophthalmoscopy methods, Retina diagnostic imaging, Retinal Neoplasms diagnosis, Retinoblastoma diagnosis, Tomography, Optical Coherence instrumentation
- Abstract
Portable, hand-held optical coherence tomography (OCT) revealed three clinically relevant yet not ophthalmoscopically detected or confirmed manifestations of retinoblastoma in a single patient with familial bilateral disease. Specifically, OCT showed new retinal tumors, new vitreous seeds, and tumor recurrence before they could be detected or confirmed by ophthalmoscopy. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:965-968.]., (Copyright 2016, SLACK Incorporated.)
- Published
- 2016
- Full Text
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9. Retained Intraocular Perfluoro-n-octane After Valved Cannula Pars Plana Vitrectomy for Retinal Detachment.
- Author
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Oellers P, Schneider EW, Fekrat S, Mahmoud TH, Mruthyunjaya P, and Hahn P
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- Adult, Aged, Female, Humans, Male, Microbubbles, Middle Aged, Retinal Detachment physiopathology, Retrospective Studies, Visual Acuity physiology, Vitrectomy instrumentation, Vitreous Body chemistry, Endotamponade, Eye Foreign Bodies etiology, Fluorocarbons, Retinal Detachment surgery, Vitrectomy methods
- Abstract
Background and Objective: To investigate cases of retained intraocular perfluoro-n-octane (PFO) after pars plana vitrectomy (PPV) for retinal detachment (RD)., Patients and Methods: Retrospective, noncomparative case series of six eyes with retained intraocular PFO after RD repair. Clinical data were supplemented with an experimental silicone eye model., Results: A cluster of six cases of retained intraocular PFO after PPV for RD repair were noted shortly after transitioning to valved cannulas. PFO was noted in the anterior chamber (AC) and/or vitreous and removed with AC paracentesis, AC wash-out, and/or PPV. A silicone eye model demonstrated that PFO levels are maintained anterior to cannula insertion with valved cannulas only., Conclusion: The authors hypothesize that anterior PFO fill using valved cannulas can lead to sequestration within the AC, zonules, ciliary sulcus, ciliary teeth, and/or capsular bag. They suggest vigilance in not overfilling PFO, particularly when transitioning to use of valved cannulas, to minimize the risk of intraocular retention., (Copyright 2015, SLACK Incorporated.)
- Published
- 2015
- Full Text
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10. Choroidal metastatasis from a neuroendocrine tumor masquerading as choroidal melanoma.
- Author
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Yiu G, Cummings TJ, and Mruthyunjaya P
- Subjects
- Aged, Choroid Neoplasms diagnosis, Diagnosis, Differential, Humans, Male, Neuroendocrine Tumors diagnosis, Bruch Membrane pathology, Choroid pathology, Choroid Neoplasms secondary, Melanoma diagnosis, Neuroendocrine Tumors secondary, Pancreatic Neoplasms pathology
- Abstract
A mushroom-shaped choroidal mass is classically suggestive of melanoma, due to the ability of these tumors to erupt through Bruch's membrane. In contrast, choroidal metastases rarely adopt this growth pattern. The authors present an unusual case of a patient with a large choroidal metastasis from a pancreatic neuroendocrine tumor that shows a collar-button configuration. The diagnosis was confirmed by histology and immunohistochemistry following enucleation. The authors review the typical appearance of choroidal metastases from neuroendocrine tumors and discuss mechanisms by which uveal tumors may extend through Bruch's membrane., (Copyright 2014, SLACK Incorporated.)
- Published
- 2014
- Full Text
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11. Combination therapy for macular edema secondary to retinal vein occlusion.
- Author
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Schneider EW, Mruthyunjaya P, and Hariprasad SM
- Subjects
- Combined Modality Therapy methods, Drug Therapy, Combination methods, Humans, Macular Edema etiology, Vascular Endothelial Growth Factor A antagonists & inhibitors, Adrenal Cortex Hormones therapeutic use, Angiogenesis Inhibitors therapeutic use, Laser Therapy, Macular Edema therapy, Retinal Vein Occlusion complications
- Published
- 2013
- Full Text
- View/download PDF
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