1. Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake
- Author
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Parisa Shokryazdan, Juan Boo Liang, Fatemeh Bashokouh, Zulkifli Idrus, Rohollah Ebrahimi, and Mohammd Faseleh Jahromi
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Article Subject ,medicine.medical_treatment ,Gene Expression ,Immunoglobulins ,Oligosaccharides ,lcsh:Medicine ,Arecaceae ,Antioxidants ,General Biochemistry, Genetics and Molecular Biology ,Rats, Sprague-Dawley ,Lipid peroxidation ,Random Allocation ,03 medical and health sciences ,Basal (phylogenetics) ,chemistry.chemical_compound ,Immune system ,Palm kernel ,Internal medicine ,medicine ,Animals ,Cecum ,Protein kinase C ,Mannan ,General Immunology and Microbiology ,biology ,Plant Extracts ,Prebiotic ,lcsh:R ,0402 animal and dairy science ,04 agricultural and veterinary sciences ,General Medicine ,040201 dairy & animal science ,Rats ,Jejunum ,030104 developmental biology ,Endocrinology ,Liver ,Biochemistry ,chemistry ,Seeds ,biology.protein ,Cytokines ,Lipid Peroxidation ,Antibody ,Research Article - Abstract
To investigate the prebiotic and immunomodulatory effects of PKC extract (OligoPKC) a total of 24 male rats were randomly assigned to three treatment groups receiving basal diet (control), basal diet containing 0.5% OligoPKC, or basal diet containing 1% OligoPKC for four weeks. We found that OligoPKC had no significant effect on the tested growth parameters. However, it increased the size of the total and beneficial bacterial populations while reducing pathogen populations. OligoPKC increased the concentration of immunoglobulins in the serum and cecal contents of rats. It also enhanced the antioxidant capacity of the liver while reducing lipid peroxidation in liver tissue. OligoPKC affected the expression of genes involved in immune system function in the intestine. Therefore, OligoPKC could be considered a potential mannan-based prebiotic for humans and animals due to its beneficial effects on the health and well-being of the model rats.
- Published
- 2017
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