1. Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis
- Author
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Ancuta Goriuc, Sorina Solomon, Ioana Martu, Maria Alexandra Martu, Silvia Mârțu, Silvia Teslaru, Diana Cristala Kappenberg-Nitescu, Ionut Luchian, and Alexandra Cornelia Teodorescu
- Subjects
lcsh:Immunologic diseases. Allergy ,Adult ,Male ,musculoskeletal diseases ,medicine.medical_specialty ,Article Subject ,Immunology ,Inflammation ,Hemorrhage ,Bone remodeling ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Osteoprotegerin ,Internal medicine ,medicine ,Immunology and Allergy ,Aggressive periodontitis ,Humans ,Receptor ,Periodontitis ,Saliva ,biology ,business.industry ,RANK Ligand ,030206 dentistry ,General Medicine ,Middle Aged ,medicine.disease ,Chronic periodontitis ,Up-Regulation ,Endocrinology ,RANKL ,030220 oncology & carcinogenesis ,Acute Disease ,Chronic Disease ,biology.protein ,Female ,Bone Remodeling ,medicine.symptom ,lcsh:RC581-607 ,business ,Research Article - Abstract
RANKL (receptor activator of nuclear factor kappa-βligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared with that of OPG, the RANKL is available to bond with RANK (receptor activator of nuclear factor kappa-β). This study was conducted on 41 patients: 19 with generalized aggressive periodontitis, 18 with severe chronic periodontitis, and 4 periodontal healthy subjects. For each patient included, we determined the salivary levels of RANKL and OPG with the help of two Human ELISA kits. The results show that the patients affected by periodontitis, either aggressive or chronic, have significant higher values of RANKL and RANKL/OPG ratio. This values correlate with the local inflammation status.
- Published
- 2019
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