1. The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review.
- Author
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Luo, Pan, Gao, Fuqiang, Niu, Dongsheng, Sun, Xichun, Song, Qiang, Guo, Chongjun, Liang, Yuqi, and Sun, Wei
- Subjects
OSTEOARTHRITIS treatment ,AUTOPHAGY ,APOPTOSIS ,CARTILAGE cells ,CELL death ,CELLULAR aging ,NUTRITIONAL requirements ,DISEASE progression ,OSTEOARTHRITIS ,PREVENTION - Abstract
Chondrocytes are the sole cellular constituents of normal cartilage. The degeneration and apoptosis of these cells are considered the main cause of osteoarthritis (OA). Previous studies have suggested that the enhancement of autophagy in chondrocytes can delay the progression of osteoarthritis by affecting intracellular metabolic activity, i.e., by regulating the metabolism of nutrients, which can delay cell aging and death. In this review, we explored the relationship between autophagy and chondrocyte metabolism and provided new ideas for the prevention and treatment of OA. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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