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In order to study the evolution process and hydraulic characteristics of pressurizer insurge in CPR1000 pressurized water reactor (PWR), the computational fluid dynamics (CFD) of three-dimensional unsteady heat transfer was used to capture the temperature and velocity fluctuation intensity of the mixing of the hot and cold. The results show that Realizable k–ε Turbulence Model combined with VOF multiphase heat transfer model can effectively predict the development trend of pressurizer insurge process. The small diameter pressurizer surge line of CPR1000 enhances the intensity of velocity fluctuation. From the essence of flow and heat transfer, it is concluded that buoyancy force can increase the degree of fluctuation and make an accelerated effect on the influx cold fluid. The electric heater inside the pressurizer should be arranged as far as possible in z<-0.45m and z>0.45m; it is beneficial to improve its harsh operating environment. This research can provide reference for the structural design of pressurizer and the layout optimization of the electric heater. [ABSTRACT FROM AUTHOR]

Scaffolds play an important role in tissue engineering and their structure and biocompatibility have great influence on cell behaviors. In this study, poly(l-lactide-co-ε-caprolactone) (PLCL) scaffolds were printed by a 3D printing technology, low-temperature deposition manufacturing (LDM), and then PLCL scaffolds were treated by alkali and coated with collagen type I (COLI). The scaffolds were characterized by scanning electron microscopy (SEM), porosity test, mechanical test, and infrared spectroscopy. The prepared PLCL and PLCL-COLI scaffolds had three-dimensional (3D) porous structure and they not only have macropores but also have micropores in the deposited lines. Although the mechanical property of PLCL-COLI was slightly lower than that of PLCL scaffold, the hydrophilicity of PLCL-COLI was significantly enhanced. Rabbit articular chondrocytes were extracted and were identified as chondrocytes by toluidine blue staining. To study the biocompatibility, the chondrocytes were seeded on scaffolds for 1, 3, 5, 7, and 10 days. MTT assay showed that the proliferation of chondrocytes on PLCL-COLI scaffold was better than that on PLCL scaffold. And the morphology of cells on PLCL-COLI after 1-day culture was much better than that on PLCL. This 3D-printed PLCL scaffold coated with COLI shows a great potential application in tissue engineering. [ABSTRACT FROM AUTHOR]