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Variability and availability of water resources under changing environment in a regional scale have been hot topics in recent years, due to the vulnerability of water resources associated with social and economic development. In this paper, four subbasins in the Dongjiang basin with a significant land use change were selected as case study. Runoffs of the four subbasins were simulated using the SCS monthly model to identify the quantitative impacts of land use and climate change. The results showed that (1), in the Dongjiang basin, temperature increased significantly, evaporation and sunlight decreased strongly, while precipitation showed a nonsignificant increase; (2) since the 1980s, land uses in the Dongjiang basin have experienced a significant change with a prominent increase inurbanareas, amoderate increase in farmlands, anda greatdecrease inforest areas; (3) the SCSmonthlymodel performed well in the four subbasins giving that the more significant land use change in each subbasin, the more runoff change correspondingly; (4) overall, runoff change was contributed half and half by climate change and human activities, respectively, in all the subbasins, in which about 20%~30% change was contributed by land use change. [ABSTRACT FROM AUTHOR]