Author: "Guo, Jian" / Publisher: hindawi limited / Topic: androgen receptors and biological models - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Guo, Jian" Topic androgen receptors Topic biological models Publisher hindawi limited

Author: Hu, Suqin, Liu, Dianlong, Liu, Sijia, Li, Chunrui, and Guo, Jian
Subjects: *EPITHELIAL cells, *POLYSACCHARIDES, *TESTIS, *BIOLOGICAL models, *PROTEIN kinases, *MEDICINAL plants, *PHYSIOLOGICAL effects of heat, *ANIMAL experimentation, *RATS, *GENE expression, *CELLULAR signal transduction, *CELL proliferation, *PLANT extracts, *ANDROGEN receptors, *PHOSPHORYLATION, *BLOOD, *CELL physiology
Abstract: Male infertility induced by heat stress has been attracting more and more attention. Heat stress not only causes apoptosis of spermatocytes but also has adverse effects on Sertoli cells, further damaging spermatogenesis. Lycium barbarum polysaccharide (LBP) is the main bioactive component of Lycium barbarum, which has a protective effect on male reproduction, but its mechanism is still unclear. In this study, our results proved that LBP blocked the inhibitory effect on the proliferation activity of Sertoli cells after heat stress, reversed the dedifferentiation of Sertoli cells induced by heat stress, and ameliorated the structural integrity of the blood-testis barrier. In addition, it increased the expression of the androgen receptor and activated Akt signaling pathway to resist heat-stress-induced injury of Sertoli cells. [ABSTRACT FROM AUTHOR]
Published: 2021
Full Text: View/download PDF

Author: Hu, Suqin, Liu, Dianlong, Liu, Sijia, Li, Chunrui, and Guo, Jian
Subjects: *POLYSACCHARIDES, *TESTIS, *BIOLOGICAL models, *CELL differentiation, *MEDICINAL plants, *PHYSIOLOGICAL effects of heat, *ANIMAL experimentation, *CELL physiology, *INFERTILITY, *CELLULAR signal transduction, *RATS, *TRANSFERASES, *CELL proliferation, *EPITHELIAL cells, *ANDROGEN receptors, *MOLECULAR structure, *CHINESE medicine, *PHOSPHORYLATION
Abstract: Male infertility induced by heat stress has been attracting more and more attention. Heat stress not only causes apoptosis of spermatocytes but also has adverse effects on Sertoli cells, further damaging spermatogenesis. Lycium barbarum polysaccharide (LBP) is the main bioactive component of Lycium barbarum, which has a protective effect on male reproduction, but its mechanism is still unclear. In this study, our results proved that LBP blocked the inhibitory effect on the proliferation activity of Sertoli cells after heat stress, reversed the dedifferentiation of Sertoli cells induced by heat stress, and ameliorated the structural integrity of the blood-testis barrier. In addition, it increased the expression of the androgen receptor and activated Akt signaling pathway to resist heat-stress-induced injury of Sertoli cells. [ABSTRACT FROM AUTHOR]
Published: 2021
Full Text: View/download PDF

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