1. Survival of AIDS Patients Treated with Traditional Chinese Medicine in Rural Central China: A Retrospective Cohort Study, 2004-2012.
- Author
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Yantao Jin, Xin Wang, Zhengwei Li, Ziqiang Jiang, Huijun Guo, Zhibin Liu, and Liran Xu
- Subjects
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ANTIRETROVIRAL agents , *AGE distribution , *AIDS patients , *ALTERNATIVE medicine , *COMBINED modality therapy , *CONFIDENCE intervals , *LONGITUDINAL method , *CHINESE medicine , *MORTALITY , *PROBABILITY theory , *RESEARCH funding , *RURAL health , *SEX distribution , *SURVIVAL , *STATISTICAL significance , *EDUCATIONAL attainment , *PROPORTIONAL hazards models , *RETROSPECTIVE studies , *DATA analysis software , *DESCRIPTIVE statistics , *KAPLAN-Meier estimator , *CD4 lymphocyte count , *LOG-rank test , *ODDS ratio - Abstract
This study aimed to explore the survival of AIDS patients treated with traditional Chinese medicine (TCM) in addition to combined antiretroviral therapy (cART) and of AIDS patients treated with cART. Data of patients taking cART between 30 October 2003 and 30 October 2004 in the National TCM HIV Treatment Trial Program area were retrospectively analyzed, with follow-up from 30 October 2004 to 30 October 2012. The log-rank test was used to compare survival between the two groups. A Cox proportional hazards model was used to determine hazard ratios to identify prognostic factors. The study included 521 patients in the TCM + cART group followed up for 3548 person-years and 375 patients in the cART group followed up for 2523 person-years. Mortality rates were 3.2/100 person-years and 4.2/100 person-years in the TCM + cART and cART groups, respectively. The difference in survival was significant. After adjusting for explanatory variables, the mortality rate of AIDS patients in the cART group was 1.7 times higher than in the TCM + cART group. Male sex, older age, little education, and lower CD4 cell count were risk factors for mortality. TCM intervention in addition to cART could increase survival of AIDS patients. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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