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Bone marrow transplant (BMT) is an effective surgical treatment for bone marrow-related disorders. However, several associated risk factors can impair long-term survival after BMT. Machine learning (ML) technologies have been proven useful in survival prediction of BMT receivers along with the influences that limit their resilience. In this study, an efficient classification model predicting the survival of children undergoing BMT is presented using a public dataset. Several supervised ML methods were investigated in this regard with an 80-20 train-test split ratio. To ensure prediction with minimal time and resources, only the top 11 out of the 59 dataset features were considered using Chi-square feature selection method. Furthermore, hyperparameter optimization (HPO) using the grid search cross-validation (GSCV) technique was adopted to increase the accuracy of prediction. Four experiments were conducted utilizing a combination of default and optimized hyperparameters on the original and reduced datasets. Our investigation revealed that the top 11 features of HPO had the same prediction accuracy (94.73%) as the entire dataset with default parameters, however, requiring minimal time and resources. Hence, the proposed approach may aid in the development of a computer-aided diagnostic system with satisfactory accuracy and minimal computation time by utilizing medical data records. [ABSTRACT FROM AUTHOR]

Heart failure is a chronic cardiac condition characterized by reduced supply of blood to the body due to impaired contractile properties of the muscles of the heart. Like any other cardiac disorder, heart failure is a serious ailment limiting the activities and curtailing the lifespan of the patient, most often resulting in death sooner or later. Detection of survival of patients with heart failure is the path to effective intervention and good prognosis in terms of both treatment and quality of life of the patient. Machine learning techniques can be critical in this regard since they can be used to predict the survival of patients with heart failure in advance, allowing patients to receive appropriate treatment. Hence, six supervised machine learning algorithms have been studied and applied to analyze a dataset of 299 individuals from the UCI Machine Learning Repository and predict their survivability from heart failure. Three distinct approaches have been followed using Decision Tree Classifier, Logistic Regression, Gaussian Naïve Bayes, Random Forest Classifier, K-Nearest Neighbors, and Support Vector Machine algorithms. Data scaling has been performed as a preprocessing step utilizing the standard and min–max scaling method. However, grid search cross-validation and random search cross-validation techniques have been employed to optimize the hyperparameters. Additionally, the synthetic minority oversampling technique and edited nearest neighbor (SMOTE-ENN) data resampling technique are utilized, and the performances of all the approaches have been compared extensively. The experimental results clearly indicate that Random Forest Classifier (RFC) surpasses all other approaches with a test accuracy of 90% when used in combination with SMOTE-ENN and standard scaling technique. Therefore, this comprehensive investigation portrays a vivid visualization of the applicability and compatibility of different machine learning algorithms in such an imbalanced dataset and presents the role of the SMOTE-ENN algorithm and hyperparameter optimization for enhancing the performances of the machine learning algorithms. [ABSTRACT FROM AUTHOR]