1. Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients
- Author
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Jozélio Freire de Carvalho, Licia Maria Henrique Mota, Carla G. S. Saad, Nadia E. Aikawa, Ana C. Medeiros, Karla R. Castro, Julio C. B. Moraes, Eloisa Bonfa, and Clovis A. Silva
- Subjects
Adult ,Male ,lcsh:Immunologic diseases. Allergy ,medicine.medical_specialty ,Article Subject ,Immunology ,Cholesterol, VLDL ,Arthritis ,Gastroenterology ,chemistry.chemical_compound ,Psoriatic arthritis ,Prednisone ,Internal medicine ,medicine ,Immunology and Allergy ,Humans ,Prospective Studies ,Triglycerides ,medicine.diagnostic_test ,Triglyceride ,biology ,Cholesterol ,business.industry ,C-reactive protein ,Arthritis, Psoriatic ,Cholesterol, HDL ,Antibodies, Monoclonal ,General Medicine ,Cholesterol, LDL ,Middle Aged ,medicine.disease ,Lipid Metabolism ,Infliximab ,Endocrinology ,C-Reactive Protein ,chemistry ,Antirheumatic Agents ,biology.protein ,Female ,business ,Lipid profile ,lcsh:RC581-607 ,medicine.drug ,Research Article - Abstract
Objectives. To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic arthritis (PsA).Methods. Fifteen PsA patients (eight polyarticular, four oligoarticular, two axial, and one mutilating) under infliximab were included. None had dyslipoproteinemia or previous statin use. Total cholesterol (TC) and its fractions, inflammatory markers, and prednisone use were evaluated.Results. The comparisons of lipid levels between baseline and after three months (3M) of anti-TNF therapy showed that there was a significant increase in mean triglycerides (117.8±49.7versus140.1±64.1 mg/dL,P=0.028) and VLDL-c (23.6±10.5versus28.4±13.7 mg/dL,P=0.019) levels. In contrast, there were no differences in the mean TC (P=0.28), LDL-c (P=0.42), and HDL-c (P=0.26) levels. Analysis of the frequencies of each lipid alteration at baseline and at 3M were alike (P>0.05). Positive correlations were found between VLDL-c and CRP (r=0.647,P=0.009) and between triglycerides and CRP (r=0.604,P=0.017) levels at 3M. ESR reduction was observed after 3M (P=0.04). Mean prednisone dose remained stable at beginning and at 3M (P=0.37).Conclusion. This study demonstrated that anti-TNF may increase TG and VLDL-c levels in PsA patients after three months.
- Published
- 2011