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In order to improve the spatial layout ability of ecological buildings under the background of rural revitalization, a multiobjective planning and decision-making model for the spatial layout of ecological buildings is constructed. Based on the visual impact detection of ecological building space, a three-dimensional rendering model is established. The block matrix matching and boundary contour parameter analysis methods are used to plan and design the layout boundary feature points, and the wavelet scale decomposition method is used to analyze the mixed tone of the layout image. Based on this, a multiobjective planning decision-making model for the spatial layout of ecological buildings is established, based on which the spatial layout design scheme of ecological buildings is output to realize the spatial layout planning of ecological buildings. The simulation results show that the spatial layout of ecological buildings using this method is more reasonable, and the expression ability of ecological aesthetics is stronger, which has a good application value in rural planning and design.

No effective treatment for Sjögren’s syndrome (SS), a chronic autoimmune disease affecting mainly salivary and lacrimal glands, is available now. Systemic infusion of allogeneic mesenchymal stem cells (MSCs) isolated from tissues such as bone marrow (BM) alleviated SS in mouse models and a small clinical trial, but further research and application of this MSC therapy were hindered by limited expandability, significant donor variations, and safety concerns of tissue-derived MSCs. To circumvent these issues, we derived MSCs from human iPSCs using an optimized protocol that can be easily scaled up to produce a huge amount of standardized MSCs. Our iPSC-MSCs inhibited the onset of lymphocyte infiltration into salivary glands in the NOD mouse model of SS in the same way as BM-MSCs. Extracellular vesicles (EVs) carry bioactive molecules in the same way as their originating cells and are more stable and considered much safer than cells for therapies. We found that EVs derived from BM-MSCs and iPSC-MSCs suppressed activation of immune cells and expression of proinflammation factors essential for SS progression in vitro and that infusion of iPSC-MSC EVs at the predisease stage decreased the lymphocyte infiltration in salivary glands and serum autoantibody levels in the same way as infusion of BM-MSCs and iPSC-MSCs. These data suggested that iPSC-MSC EVs have the potential to prevent the progression of SS before the onset of sialadenitis.