Search

Fluid charging and formation pressure evolution are of great significance for shale gas exploration and development. Taking the Longmaxi formation shale in southeast Chongqing as the research object, the fluid activity and pressure evolution process were studied by means of thin section observation, fluid inclusion analysis and testing, and basin numerical simulation. The results show that the area of the southeast of Chongqing, the Longmaxi formation of dike filling minerals, is mainly quartz vein and calcite part of the veins and arteries, and vein body captures the rich organic inclusions in minerals, sees fgas-liquid two-phase brine inclusions and methane inclusions, combining with the temperature and salinity of brine inclusions, and shows that the area has experienced two phases of oil and gas filling, the first period of gas-liquid fluid. The second stage is gas fluid. Combined with burial history and thermal maturation history, it is found that the filling time of oil and gas is late Cretaceous and Paleocene, respectively. In the Cretaceous, the pressure coefficient of Longmaxi formation reached the maximum value of 2.2 and remained above 1.5 overpressure after pressure unloading in the later period. In terms of the frequency of inclusions, the charging amount of the first stage is relatively large, and the charging time corresponds to the peak period of the palaeo-formation pressure. At the same time, fluid charging can timely supplement the pressure after unloading, which is conducive to high and stable production of shale gas. [ABSTRACT FROM AUTHOR]

Thrombosis is considered to be closely related to several diseases such as atherosclerosis, ischemic heart disease and stroke, as well as rheumatoid arthritis, hyperuricemia, and various inflammatory conditions. More and more studies have been focused on understanding the mechanism of molecular and cellular basis of thrombus formation as well as preventing thrombosis for the treatment of thrombotic diseases. In reality, there is considerable interest in the role of natural products and their bioactive components in the prevention and treatment of thrombosis related disorders. This paper briefly describes the mechanisms of thrombus formation on three aspects, including coagulation system, platelet activation, and aggregation, and change of blood flow conditions. Furthermore, the natural products for antithrombosis by anticoagulation, antiplatelet aggregation, and fibrinolysis were summarized, respectively. [ABSTRACT FROM AUTHOR]

Reliability of motorized spindles has a great effect on the performance and productivity of computer numerical control (CNC) machine tools for intelligent manufacturing. Condition-based maintenance (CBM) is an efficient method to prevent serious failures, to improve system reliability, and to reduce management costs for motorized spindles. However, owing to various degradation features acquired during condition monitoring, the challenge is to propose an appropriate feature to evaluate the reliability level of motorized spindles and to set up optimal CBM policies. Based on the motivation, a three-stage approach is proposed in this paper. In the first stage, proportional hazard model (PHM) is developed to describe the reliability considering failure events together with multiple degradation features. Next, statistical process control (SPC) charts are constructed for condition monitoring and anomaly detection in order to achieve early detection of potential failures. At last, a CBM schedule is modeled in consideration of maintenance cost minimization; the maintenance plan is optimized by determining the optimal control limits of SPC charts. [ABSTRACT FROM AUTHOR]

Background. Real world evidence is important for informing healthcare practice and developing medical products and has gained broad interest in healthcare. Compound Kushen Injection (CKI) has been widely applied into treatment of colon carcinoma (CC) in China. Postapproval drug assessment related retrospective studies using electrical medical record (EMR) collected from hospital information system (HIS) is one of the most important categories of real-world study (RWS). Based on HIS EMR, interrelationships of combined medication of CKI in treating CC can be validated in real world settings. Methods. This study was conducted based on a large-scale integrated database of EMR derived from HIS. EMR of 3328 patients initially diagnosed with CC among 49,597 patients treated with CKI were included in the study. Descriptive statistical analyses and apriori algorithm based association rule analyses were performed, respectively, to validate frequency distribution and interrelationships of combined medication of CKI in treating CC. Results. The pharmacological mechanisms of TCMs that have been commonly used in conjunction with CKI include heat-clearing and detoxifying, qi-reinforcing, blood circulation-promoting and stasis-removing, blood-stanching, and qi-regulating. For modern medicines, antibiotics, antineoplastic chemotherapeutic drugs, immunomodulator, 5-HT receptor antagonist drugs, and corticosteroids are most often combined with CKI. The association rules of medication combinations of CKI in treating CC in real world manifest certain laws for both TCMs and modern medicines. They are generally in line with CC treatment guidelines. Conclusions. It is a common practice for CKI to be integrated with both modern medicines and TCMs when treating CC in China. The associations of medication combinations of CKI in treating CC manifest certain laws for both TCMs and modern medicines. The RWS for validating interrelationships of combined medication may provide evidence for rational use of CKI. Further explorations are needed to verify and expand the conclusions. [ABSTRACT FROM AUTHOR]