1. Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1α and VEGF Effect on Cell Biological Behaviour.
- Author
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Xue, Tong-min, Tao, Li-de, Zhang, Miao, Zhang, Jie, Liu, Xia, Chen, Guo-feng, Zhu, Yi-jia, and Zhang, Pei-Jian
- Subjects
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MICRORNA , *LIVER cancer , *HYPOXIA-inducible factor 1 , *VASCULAR endothelial growth factors , *CYTOLOGY , *HYPOXEMIA , *KAPLAN-Meier estimator , *THERAPEUTICS , *GENETICS , *PROGNOSIS - Abstract
miRNA-20b has been shown to be aberrantly expressed in several tumor types. However, the clinical significance of miRNA-20b in the prognosis of patients with hepatocellular carcinoma (HCC) is poorly understood, and the exact role of miRNA-20b in HCC remains unclear. The aim of the present study was to investigate the association of the expression of miR-20b with clinicopathological characteristics and overall survival of HCC patients analyzed by Kaplan-Meier analysis and Cox proportional hazards regression models. Meanwhile, the HIF-1α and VEGF targets of miR-20b have been confirmed. We found not only miR-20b regulation of HIF-1α and VEGF in normal but also regulation of miR-20b in hypoxia. This mechanism would help the tumor cells adapt to the different environments thus promoting the tumor invasion and development. The whole study suggests that miR-20b, HIF-1α, and VEGF serve as a potential therapeutic agent for hepatocellular carcinoma. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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