1. A Method to Control Curcumin Release from PELA Fibers by Heat Treatment.
- Author
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Chen, Weiming, Ei‐hamshary, Hany, Al‐deyab, Salem S., and Mo, Xiumei
- Subjects
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CURCUMIN , *HEAT treatment , *POLYMERS , *CANCER chemotherapy , *POROSITY - Abstract
Abstract: Poly(ethylene glycol ‐co‐ DL‐lactide) (PELA) is a biodegradable polymer, which has attracted considerable interest in the area of drug release due to its potential as drug carrier. Drug‐loaded electrospun PELA fibers tend to be a promising candidate for local chemotherapy application in the future. In this study, curcumin was encapsulated into PELA fibers (Cur@PELA) for drug delivery via electrospinning. It was found that the shrinkage ratio, porosity, water absorption and water contact angle of Cur@PELA fiber membrane could be changed by heat treatment with different heating temperature (45°C, 50°C) and heating time (5 min, 10 min, 20 min). Moreover, the release rate of curcumin from Cur@PELA fibers was influenced by the porosity, water absorption and water contact angle of the drug‐loaded membrane. Heat treatment is thought to be a novel method to control release of drug from electrospun PELA fibers. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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