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Chyawanprash, a polyherbal formulation, is popular for its nutritional value and is widely used as a tonic, rejuvenator, immunomodulator, and enhancer. This study aimed to evaluate the quality profile of five different brands of Chyawanprash marketed in Nepal. Proximate analysis, estimation of heavy metal, physicochemical analysis, determination of microbial contamination, estimation of vitamin C, and detection of heavy metals were carried out to assess the therapeutical values and compare the quality control parameters. All the analyses were carried out based on standard procedures. The data analysis revealed that the presence of moisture content (11.83 ± 1.61%–19.90 ± 0.92%), ash content (1.2–2.3%), energy (316.12 ± 1.96–363 ± 11.90 Kcal/100g), acid-insoluble ash content (0.12 ± 0.05–1.47 ± 0.26%), pH (5.12–5.34), vitamin C (9.92–28.58 mg/100g), and heavy metals was not detected in ppm in any of the brands. Chyawanprash holds tremendous amounts of nutritional value suitable for treating different types of illness. Thus, stringent quality control parameters should be implemented from the government level for product consistency and to reduce variation among different brands.

Background. Chyawanprash awaleha (Cp) is an Ayurvedic rasayana formulation and is used as a genoprotective agent. Objective. The present cytogenetic study has been done to investigate the efficacy of Cp against betel quid chewers suffering from oral precancerous lesions through satellite association (SA) assay. Materials and Methods. The frequency of SA was analyzed in 21 betel quid chewing oral precancerous lesions patients and then they were divided into 2 groups. Group 1 consisted of 15 patients, advised to quit betel quid chewing and fed with 20 gms of Cp, twice a day for three months. Group 2 consisted of 6 patients, who refused Cp feed but accepted to quit betel quid chewing. At the end of three months, both groups were assessed cytogenetically. Results. The frequency of SA was statistically significant in both groups, but an elevated mean difference was observed more in Group 1 than in Group 2. Conclusion. The study indicates that betel quid cessation reduces the effect of DNA damage in oral precancerous lesions. But the increased mean difference in SA in Group 1 compared to Group 2 clearly indicates that Cp can further minimize the genotoxic effect caused by mutagenic agents present in betel quid.