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Your search keyword '"KAZUYA FUJIHARA"' showing total 3 results
Start Over Author "KAZUYA FUJIHARA" Publisher hindawi limited
3 results on '"KAZUYA FUJIHARA"'

1. Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes

Author

Kazuto Kobayashi, Kazumi Saito, Shigeru Yatoh, Akira Sato, Naoya Yahagi, Hirohito Sone, Hiroaki Suzuki, Hitoshi Iwasaki, Akimitsu Takahashi, Hiroaki Yagyu, Yoriko Heianza, Satoru Kodama, Kazuya Fujihara, and Hitoshi Shimano

Subjects
Adult, Male, medicine.medical_specialty, Article Subject, Endocrinology, Diabetes and Metabolism, Coronary stenosis, Type 2 diabetes, Coronary Angiography, lcsh:Diseases of the endocrine glands. Clinical endocrinology, behavioral disciplines and activities, Asymptomatic, chemistry.chemical_compound, Endocrinology, Japan, Malondialdehyde, Diabetes mellitus, Internal medicine, medicine, Humans, skin and connective tissue diseases, Aged, Retrospective Studies, lcsh:RC648-665, Receiver operating characteristic, Cholesterol, business.industry, Cholesterol, HDL, Coronary Stenosis, Retrospective cohort study, Cholesterol, LDL, Middle Aged, medicine.disease, Lipoproteins, LDL, Logistic Models, Diabetes Mellitus, Type 2, chemistry, Area Under Curve, Cardiology, Female, lipids (amino acids, peptides, and proteins), medicine.symptom, business, Biomarkers, Research Article
Abstract

Aims. To elucidate the levels of malondialdehyde-modified LDL (MDA-LDL)-related variables for predicting coronary artery stenosis (CAS) by coronary CT angiography (CCTA) in asymptomatic patients with type 2 diabetes (T2DM).Methods. Enrolled were 36 Japanese patients with T2DM who underwent CCTA and in whom MDA-LDL levels were measured. Definition of CAS was luminal narrowing of ≥50%. Trends through tertiles of each MDA-LDL-related variable were analyzed with a general linear model. The ability of each MDA-LDL-related variable to predict CAS was compared to areas under the curve (AUCs) in receiver operating characteristic curve (ROC) analysis.Results. Seventeen patients had CAS. Each MDA-LDL-related variable was an independent predictor of CAS (P=0.039for MDALDL,P=0.013for MDA-LDL/LDL-C,P=0.047for MDA-LDL/HDL-C, andP=0.013for (MDA-LDL/LDL-C)/HDL-C). AUCs of MDA-LDL, MDA-LDL/LDL-C, MDA-LDL/HDL-C, and (MDA-LDL/LDL-C)/HDL-C were 0.675 (95% CI 0.496–0.854), 0.765 (0.602–0.927), 0.752 (0.592–0.913), and 0.799 (0.643–0.955), respectively, for predicting CAS. Trends throughout the tertiles showed significant associations between MDA-LDL/LDL-C, MDA-LDL/HDL-C, or (MDALDL/LDL-C)/HDL-C and CAS (P=0.003for MDA-LDL/LDL-C,P=0.042for MDA-LDL/HDL-C, andP=0.001for (MDA-LDL/LDL-C)/HDL-C).Conclusions. Data suggest that measurements of MDA-LDL/LDL-C, MDA-LDL/HDLC, and (MDA-LDL/LDL-C)/HDL-C are useful for predicting CAS.

Published
2015

2. Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis.

Author

Chika Horikawa, Satoru Kodama, Kazuya Fujihara, Yoko Yachi, Shiro Tanaka, Akiko Suzuki, Osamu Hanyu, Hitoshi Shimano, and Hirohito Sone

Subjects
HELICOBACTER pylori infections, META-analysis, ENDOCRINE diseases, INSULIN pumps, GLUCOSE intolerance
Abstract

Objective. To assess the association between Helicobacter pylori (HP) infection and glycemic control in patients with diabetes through a meta-analytic approach. Research Design and Methods. Electronic literature searches were conducted for cross-sectional studies that examined the hemoglobin A1c (A1C) level by whether patients with diabetes were or were not carriers of HP. Mean differences in A1C between groups with and without HP infection were pooled with a random-effects model. Results. Thirteen eligible studies were included in this meta-analysis. Overall, the HP carriers did not have significantly higher A1C levels compared with HP noncarriers (mean difference (95% CI), 0.19% (-0.18 to 0.46), P = 0.16). When the analysis was limited to studies targeting patients with type 1 diabetes, there was also no significant difference in A1C (0.69% (-0.31 to 1.68), P = 0.18). Conclusions. There was insufficient evidence that HP infection worsened glycemic control in patients with diabetes. [ABSTRACT FROM AUTHOR]

Published
2014
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3. The Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome: A Meta-Analysis.

Author

Kazuya Fujihara, Satoru Kodama, Chika Horikawa, Sakiko Yoshizawa, Ayumi Sugawara, Reiko Hirasawa, Hitoshi Shimano, Yoko Yachi, Akiko Suzuki, Osamu Hanyu, and Hirohito Sone

Subjects
*DIABETIC nephropathies, *SLEEP apnea syndromes, *META-analysis, *CROSS-sectional method, *PEOPLE with diabetes, *COMPARATIVE studies, *DIAGNOSIS
Abstract

Aims. High prevalence of sleep apnea syndrome (SAS) has been reported in patients with diabetes. However, whether diabetic neuropathy (DN) contributes to this high prevalence is controversial. Our aim of this study is to compare the prevalence of SAS between patients with and without DN. Methods. Systematic literature searches were conducted for cross-sectional studies that reported the number of patients with DN and SAS using MEDLINE (from1966 to Nov 5, 2012) and EMBASE (from 1974 to Nov 5, 2012). Odds ratios (ORs) of SAS related to DN were pooled with the Mantel-Haenszel method. Results. Data were obtained from 5 eligible studies (including 6 data sets, 880 participants, and 429 cases).Overall, the pooled OR of SAS in patients with DN compared with that in non-DN patients was significant (OR (95% CI), -1.95 (1.03-3.70)). The pooled OR of SAS was 1.90 (0.97-3.71) in patients with type 2 diabetes. Excluding data on patients with type 1 diabetes, a higher OR was observed in younger patients (mean age <60 years) than in those ≥60 years among whom the OR remained significant (3.82; 95% CI, 2.24-6.51 and 1.17; 95% CI, 0.81-1.68). Conclusions. Current meta-analysis suggested the association of some elements of neuropathy with SAS in type 2 diabetes. Further investigations are needed to clarify whether the association is also true for patients with type 1 diabetes. [ABSTRACT FROM AUTHOR]

Published
2013
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