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To improve traffic efficiency and utilization of road resources and alleviate traffic congestion caused by imbalance of bidirectional traffic flow, in view of the conversion conditions of reversible lane function, the operating characteristics of associated intersections under dynamic reversible lanes are analysed in terms of capacity, and a reversible lane control model is constructed based on short-term traffic flow prediction. On this basis, the reversible lane segment clearing time and upstream and downstream signal control strategies under different states are studied. The collaborative control model of reversible lane clearing time and signal timing of associated intersections is established to obtain the optimal time for reversible lane function switching. Finally, using Chaoyang Road, Beijing, as an example, the effectiveness of the proposed model is verified by the simulation indexes of average vehicle delay and reversible lane clearing time. The results show that the optimized clearing efficiency exceeds 15% and the optimized average vehicle delay is reduced by more than 10%. Combined with the future traffic state, the traffic capacity and saturation flow are greatly improved, and the intelligent reversible lane control is better achieved., Author(s): Xiaolan Xie [1,2]; Luxi Dong (corresponding author) [3,4]; Huinan Gu [5]; Hailing Li [3]; Lieping Zhang [4] 1. Introduction In the case of limited supply of urban road resources, [...]

It is reported that different microRNA (miRNA) profiles can be detected in the blood of cancer patients. We investigated that whether the key serum miRNAs could discriminate patients with and without breast cancer. This study was divided into three parts: (1) miRNA marker discovery using SOLiD sequencing-based miRNA profiling on cancerous and adjacent noncancerous breast tissue of one breast cancer patient; (2) marker selection and validation by real-time PCR on a small set of serum; (3) gene ontology analysis of the key miRNA target genes. Of genome-wide tissue miRNA expression analysis, five miRNAs were found to be altered more than fivefold by SOLiD sequencing (i.e., miR-29a, miR-23a, miR-23b, miR-192, and miR-21). All the five miRNAs were validated on the 20 breast cancer patients and 20 controls. miR-29a and miR-21 were significantly increased in the serum of breast cancer patients (P < .05). Gene ontology analysis of the target genes revealed enrichment for special biological process categories, that is, signal transduction, development, apoptosis, cell proliferation, and cell adhesion. SOLiD sequencing provides a promising method for cancer-related miRNA profiling. Serum miRNAs may be useful biomarkers for breast cancer detection., 1. Introduction Recently, microRNAs (miRNAs), small noncoding RNAs of -22 nucleotides (nt) in length, have been implicated in several carcinogenic processes by acting either as tumor suppressors or oncogenes. Studies [...]