1. The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration
- Author
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Yong-Sheng Yu, Jianjun Hu, Wen Guan, Huili Lu, Guoqiang Zang, Yan Yu, Xiaolan Yu, Quanhui Tan, and Zhenghao Tang
- Subjects
0301 basic medicine ,Cirrhosis ,Kupffer Cells ,medicine.drug_class ,lcsh:Medicine ,Review Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,medicine ,Humans ,Gene ,Hepatitis ,General Immunology and Microbiology ,business.industry ,Liver Diseases ,lcsh:R ,Interleukin ,General Medicine ,medicine.disease ,Receptor antagonist ,Liver regeneration ,Liver Regeneration ,Interleukin 1 Receptor Antagonist Protein ,030104 developmental biology ,Hepatocellular carcinoma ,Immunology ,Signal transduction ,business ,Interleukin-1 ,Signal Transduction - Abstract
Interleukin-1 (IL-1) family and Kupffer cells are linked with liver regeneration, but their precise roles remain unclear. IL-1 family members are pleiotropic factors with a range of biological roles in liver diseases, inducing hepatitis, cirrhosis, and hepatocellular carcinoma, as well as liver regeneration. Kupffer cells are the main source of IL-1 and IL-1 receptor antagonist (IL-1Ra), the key members of IL-1 family. This systemic review highlights a close association of IL-1 family members and Kupffer cells with liver regeneration, although their specific roles are inconclusive. Moreover, IL-1 members are proposed to induce effects on liver regeneration through Kupffer cells.
- Published
- 2016