1. Mother's pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood
- Author
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Fida Bacha, Hong Chang Tan, James M. Roberts, Ramkumar Krishnamurthy, Janet M. Catov, and Roman J. Shypailo
- Subjects
medicine.medical_specialty ,Offspring ,business.industry ,Endocrinology, Diabetes and Metabolism ,Birth weight ,Gestational age ,Overweight ,Anthropometry ,medicine.disease ,Endocrinology ,Insulin resistance ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Internal Medicine ,medicine ,Lean body mass ,medicine.symptom ,business ,Body mass index - Abstract
Objective Maternal adiposity is associated with poor offspring cardiometabolic health. We aimed to evaluate the relationship of maternal pre-pregnancy body mass index (BMI) on the BMI, body composition and cardiometabolic characteristics of the offspring. Methods Forty offspring of overweight/obese mothers (O-OW) and 28 offspring of normal weight mothers (O-NW) underwent evaluation of body composition, abdominal fat distribution, blood pressure measurement, fasting lipids and an oral glucose tolerance test. The anthropometric and cardiometabolic characteristics of O-OW were compared with those of O-NW, and the relationship to maternal BMI was evaluated. Results Subjects (mean age: 12.6 ± 0.4, female: 52.9%) had similar gestational age, birth weight, age, gender, and Tanner stage. However, O-OW had a significantly higher BMI (24.4 ± 1.2 vs. 19.7 ± 0.8 kg/m2, p = 0.001), % body fat (31.7 ± 1.6 vs. 24.6 ± 1.1%, p
- Published
- 2015
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