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24 results on '"Shim, Insop"'

11. Antidepressant Effect of Fraxinus rhynchophylla Hance Extract in a Mouse Model of Chronic Stress-Induced Depression.

Author

Kim, Yu Ri, Park, Bo-Kyung, Kim, Young Hwa, Shim, Insop, Kang, In-Cheol, and Lee, Mi Young

Subjects
AFFECT (Psychology), ANIMAL experimentation, BEHAVIOR, BIOCHEMISTRY, BIOLOGICAL models, CARRIER proteins, CHRONIC diseases, CYTOKINES, MENTAL depression, GENE expression, HYDROCORTISONE, LIVER, PHENOMENOLOGY, MICE, NUCLEOTIDES, RESTRAINT of patients, SEROTONIN, SHOCK (Pathology), PSYCHOLOGICAL stress, SWIMMING, WEIGHT loss, PLANT extracts, BRAIN-derived neurotrophic factor
Abstract

Prolonged exposure to stress can affect mood and cognition and lead to mood disorders. Research on stress-associated mood disorders is important in modern society as people are increasingly exposed to unavoidable stressors. We used a mouse model with 2 weeks of exposure to electric foot shock and restraint, to determine the effect of Fraxinus rhynchophylla Hance (FX) extract on chronic stress-induced depression. We measured the effect of FX extract using various physiological, behavioral, and biochemical measures. FX extract ameliorated chronic stress-induced body and relative liver weight loss and improved depressive-like behaviors in the open field and forced swim tests. In addition, plasma cortisol and serotonin levels in stress-induced mice following FX treatment were similar to normal mice, and the elevation of proinflammatory cytokines was prevented. Moreover, FX treatment increased the expression of phosphorylated cyclic adenosine-3′,5′-monophosphate response element-binding protein (pCREB)/brain-derived neurotrophic factor (BDNF). Further experiments confirmed the efficacy of FX extract by showing similar results using esculin and esculetin, compounds extracted from FX. Taken together, these results indicate that FX extract has an antidepressant effect on chronic stress-induced depression by associating signaling with neuroinflammation and neurogenesis. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Inhibitory Effects of Coptidis rhizoma and Berberine on Cocaine-induced Sensitization.

Author

Bombi Lee, Chae Ha Yang, Dae-Hyun Hahm, Eun Sang Choe, Hye-Jung Lee, Kwang-Ho Pyun, and Shim, Insop

Subjects
BERBERINE, COCAINE, ALKALOIDS, DOPAMINE, BIOGENIC amines
Abstract

Substantial evidence suggests that the behavioral and reinforcing effects of cocaine can be mediated by the central dopaminergic systems. Repeated injections of cocaine produce an increase in locomotor activity and the expression of tyrosine hydroxylase (TH) in the main dopaminergic areas. Protoberberine alkaloids affect neuronal functions. Coptidis rhizoma (CR) and its main compound, berberine (BER) reduced the dopamine content in the central nervous system. In order to investigate the effects of CR or BER on the repeated cocaine-induced neuronal and behavioral alterations, we examined the influence of CR or BER on the repeated cocaine-induced locomotor activity and the expression of TH in the brain by using immunohistochemistry. Male SD rats were given repeated injections of saline or cocaine hydrochloride (15 mg/kg, i.p. for 10 consecutive days) followed by one challenge injection on the 4th day after the last daily injection. Cocaine challenge (15 mg/kg, i.p) produced a larger increase in locomotor activity and expression of TH in the central dopaminergic areas. Pretreatment with CR (50, 100, 200 and 400 mg/kg, p.o.) and BER (200 mg/kg, p.o.) 30 min before the daily injections of cocaine significantly inhibited the cocaine-induced locomotor activity as well as TH expression in the central dopaminergic areas. Our data demonstrate that the inhibitory effects of CR and BER on the repeated cocaine-induced locomotor activity were closely associated with the reduction of dopamine biosynthesis and post-synaptic neuronal activity. These results suggest that CR and BER may be effective for inhibiting the behavioral effects of cocaine by possibly modulating the central dopaminergic system. [ABSTRACT FROM AUTHOR]

Published
2009
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