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Your search keyword '"Thennarasu, Sathiah"' showing total 2 results
Start Over Author "Thennarasu, Sathiah" Publisher hindawi limited
2 results on '"Thennarasu, Sathiah"'

2. Synthesis of Novel Pyridopyridazin-3(2H)-one Derivatives and Evaluation of Their Cytotoxic Activity against MCF-7 Cells.

Author

Selvakumar, Periasamy, Thennarasu, Sathiah, and Mandal, Asit Baran

Subjects
*BREAST cancer research, *PYRIDAZINES, *CANCER cell proliferation, *AROMATIC compound derivatives, *MALIGNANT catarrhal fever, *CELL-mediated cytotoxicity
Abstract

A series of pyridopyridazin-3(2H)-one derivatives was synthesized in two facile steps. Mannich-type three-component condensa-tion afforded the 2,6-diaryl piperidin-4-one derivatives, which underwent intramolecular cyclization in the presence of hydrazine or phenylhydrazine to yield the corresponding pyridopyridazin-3(2H)-one derivatives. All the derivatives of pyridopyridazin-3(2H)-one, except 3e and 3f, showed moderate activity against human breast adenocarcinoma (MCF-7) cells. The higher degree of inhibition of MCF-7 cell proliferation shown by 2a-2f indicates the significance of the amide proton in pyridopyridazin-3(2H)-one derivatives. [ABSTRACT FROM AUTHOR]

Published
2014
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