1. ECR-MAPK Regulation in Liver Early Development
- Author
-
Hexian Zhuo and Xiu-Ju Zhao
- Subjects
Male ,MAPK/ERK pathway ,Article Subject ,Organogenesis ,Embryonic Development ,lcsh:Medicine ,Biology ,Bioinformatics ,General Biochemistry, Genetics and Molecular Biology ,Receptor tyrosine kinase ,Transcriptome ,Alpha-Globulins ,Gene expression ,Animals ,Mitogen-Activated Protein Kinase Kinases ,Regulation of gene expression ,General Immunology and Microbiology ,Microarray analysis techniques ,lcsh:R ,Gene Expression Regulation, Developmental ,General Medicine ,Embryo, Mammalian ,Rats ,Cell biology ,Liver ,Cell culture ,Significance analysis of microarrays ,biology.protein ,Research Article - Abstract
Early growth is connected to a key link between embryonic development and aging. In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age. Meanwhile another independent animal experiment and cell culture were carried out for validation. Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated thatalpha-2u globulin(extracellular region)-socs2(-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3(MAPK signaling)-hsd3b5/cav2(metabolism/organization) plays a vital role in early development. Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations. Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.
- Published
- 2014