1. Intratumoral STING Agonist Injection Combined with Irreversible Electroporation Delays Tumor Growth in a Model of Hepatocarcinoma.
- Author
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Lasarte-Cia A, Lozano T, Cano D, Martín-Otal C, Navarro F, Gorraiz M, Casares N, Vivas I, and Lasarte JJ
- Subjects
- Animals, Cell Line, Combined Modality Therapy methods, Cyclic GMP administration & dosage, Female, Liver Neoplasms, Experimental therapy, Mice, Inbred C57BL, Mice, Ablation Techniques methods, Carcinoma, Hepatocellular therapy, Cyclic GMP analogs & derivatives, Electroporation methods, Liver Neoplasms therapy, Membrane Proteins agonists
- Abstract
Background/aim: Irreversible electroporation (IRE) showed promising results for small-size tumors and very early cancers. However, further development is needed to evolve this procedure into a more efficient ablation technique for long-term control of tumor growth. In this work, we show that it is possible to increase the antitumor efficiency of IRE by simmultaneously injecting c-di-GMP, a STING agonist, intratumorally., Materials and Methods: Intratumoral administration of c-di-GMP simultaneously to IRE was evaluated in murine models of melanona (B16.OVA) and hepatocellular carcinoma (PM299L)., Results: The combined therapy increased the number of tumor-infiltrating IFN- γ /TNF- α -producing CD4 and CD8 T cells and delayed tumor growth, as compared to the effect observed in groups treated with c-di-GMP or IRE alone., Conclusion: These results can lead to the development of a new therapeutic strategy for the treatment of cancer patients refractory to other therapies., Competing Interests: No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript., (Copyright © 2021 Aritz Lasarte-Cia et al.)
- Published
- 2021
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