1. Toward personalized cell therapies by using stem cells: seven relevant topics for safety and success in stem cell therapy.
- Author
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de Sá Silva F, Almeida PN, Rettore JV, Maranduba CP, de Souza CM, de Souza GT, Zanette Rde S, Miyagi SP, Santos Mde O, Marques MM, and Maranduba CM
- Subjects
- Animals, Cell Culture Techniques, Cell Transformation, Neoplastic pathology, Humans, Stem Cells immunology, Treatment Outcome, Precision Medicine methods, Stem Cell Transplantation adverse effects, Stem Cell Transplantation methods, Stem Cells cytology
- Abstract
Stem cells, both embryonic and adult, due to the potential for application in tissue regeneration have been the target of interest to the world scientific community. In fact, stem cells can be considered revolutionary in the field of medicine, especially in the treatment of a wide range of human diseases. However, caution is needed in the clinical application of such cells and this is an issue that demands more studies. This paper will discuss some controversial issues of importance for achieving cell therapy safety and success. Particularly, the following aspects of stem cell biology will be presented: methods for stem cells culture, teratogenic or tumorigenic potential, cellular dose, proliferation, senescence, karyotyping, and immunosuppressive activity.
- Published
- 2012
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