8 results on '"Scotti MT"'
Search Results
2. Secondary Metabolites with Antioxidant Activities for the Putative Treatment of Amyotrophic Lateral Sclerosis (ALS): "Experimental Evidences".
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Silva JM, Nobre MSC, Albino SL, Lócio LL, Nascimento APS, Scotti L, Scotti MT, Oshiro-Junior JA, Lima MCA, Mendonça-Junior FJB, and Moura RO
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- Amyotrophic Lateral Sclerosis drug therapy, Animals, Disease Models, Animal, Humans, Motor Neurons metabolism, Amyotrophic Lateral Sclerosis metabolism, Antioxidants metabolism, Motor Neurons pathology, Oxidative Stress physiology, Secondary Metabolism physiology
- Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder that is characterized by progressive loss of the upper and lower motor neurons at the spinal or bulbar level. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain are factors that contribute to neurodegeneration and perform a potential role in the pathogenesis of ALS. Natural antioxidant molecules have been proposed as an alternative form of treatment for the prevention of age-related neurological diseases, in which ALS is included. Researches support that regulations in cellular reduction/oxidation (redox) processes are being increasingly implicated in this disease, and antioxidant drugs are aimed at a promising pathway to treatment. Among the strategies used for obtaining new drugs, we can highlight the isolation of secondary metabolite compounds from natural sources that, along with semisynthetic derivatives, correspond to approximately 40% of the drugs found on the market. Among these compounds, we emphasize oxygenated and nitrogenous compounds, such as flavonoids, coumarins, and alkaloids, in addition to the fatty acids, that already stand out in the literature for their antioxidant properties, consisting in a part of the diets of millions of people worldwide. Therefore, this review is aimed at presenting and summarizing the main articles published within the last years, which represent the therapeutic potential of antioxidant compounds of natural origin for the treatment of ALS., Competing Interests: The authors declare no conflict of interests regarding the publication of this paper., (Copyright © 2020 Jamire M. Silva et al.)
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- 2020
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3. Identification of New Targets and the Virtual Screening of Lignans against Alzheimer's Disease.
- Author
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Dos Santos Maia M, Rodrigues GCS, de Sousa NF, Scotti MT, Scotti L, and Mendonça-Junior FJB
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- Algorithms, Cyclic Nucleotide Phosphodiesterases, Type 5 chemistry, Cyclic Nucleotide Phosphodiesterases, Type 5 metabolism, Databases, Chemical, Humans, Hydrogen Bonding, Lignans chemistry, Molecular Docking Simulation, Protein Tyrosine Phosphatase, Non-Receptor Type 1 chemistry, Protein Tyrosine Phosphatase, Non-Receptor Type 1 metabolism, Quantitative Structure-Activity Relationship, ROC Curve, Thermodynamics, Alzheimer Disease drug therapy, Drug Evaluation, Preclinical, Lignans analysis, Lignans therapeutic use, User-Computer Interface
- Abstract
Alzheimer's disease (AD) is characterized by the progressive disturbance in cognition and affects approximately 36 million people, worldwide. However, the drugs used to treat this disease are only moderately effective and do not alter the course of the neurodegenerative process. This is because the pathogenesis of AD is mainly associated with oxidative stress, and current drugs only target two enzymes involved in neurotransmission. Therefore, the present study sought to identify potential multitarget compounds for enzymes that are directly or indirectly involved in the oxidative pathway, with minimal side effects, for AD treatment. A set of 159 lignans were submitted to studies of QSAR and molecular docking. A combined analysis was performed, based on ligand and structure, followed by the prediction of absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. The results showed that the combined analysis was able to select 139 potentially active and multitarget lignans targeting two or more enzymes, among them are c-Jun N-terminal kinase 3 (JNK-3), protein tyrosine phosphatase 1B (PTP1B), nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1), NADPH quinone oxidoreductase 1 (NQO1), phosphodiesterase 5 (PDE5), nuclear factor erythroid 2-related factor 2 (Nrf2), cycloxygenase 2 (COX-2), and inducible nitric oxide synthase ( i NOS). The authors conclude that compounds (06) austrobailignan 6, (11) anolignan c, (19) 7-epi-virolin, (64) 6-[(2 R ,3 R ,4 R ,5 R )-3,4-dimethyl-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]-4-methoxy-1,3-benzodioxole, (116) ococymosin, and (135) mappiodoinin b have probabilities that confer neuroprotection and antioxidant activity and represent potential alternative AD treatment drugs or prototypes for the development of new drugs with anti-AD properties., Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper., (Copyright © 2020 Mayara dos Santos Maia et al.)
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- 2020
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4. Natural Bioactive Products with Antioxidant Properties Useful in Neurodegenerative Diseases.
- Author
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Mendonça-Junior FJB, Scotti MT, Nayarisseri A, Zondegoumba ENT, and Scotti L
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- Antioxidants pharmacology, Biological Products pharmacology, Humans, Neurodegenerative Diseases pathology, Antioxidants therapeutic use, Biological Products therapeutic use, Neurodegenerative Diseases drug therapy
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- 2019
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5. 2-Allylphenol Reduces IL-1 β and TNF- α , Promoting Antinociception through Adenosinergic, Anti-Inflammatory, and Antioxidant Mechanisms.
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Aragão Neto HC, da Fonsêca DV, Braga RM, Scotti MT, do Nascimento TWAB, Assis DB, Rodrigues-Mascarenhas S, Silva LHAC, Galvão JGFM, Rocha HAO, Vidal AAJ, Filho JMB, and de Almeida RN
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- Animals, Male, Mice, Molecular Docking Simulation, Peritonitis drug therapy, Peritonitis metabolism, Peritonitis pathology, Phenols chemistry, Receptor, Adenosine A2A chemistry, Receptor, Adenosine A2A metabolism, Analgesics pharmacology, Anti-Inflammatory Agents pharmacology, Antioxidants pharmacology, Interleukin-1beta metabolism, Phenols pharmacology, Tumor Necrosis Factor-alpha metabolism
- Abstract
2-Allylphenol (2-AP) is a synthetic phenylpropanoid, structurally related to cardanol, thymol, and ortho-eugenol. Phenylpropanoids are described in the literature as being capable of promoting biological activity. Due to the similarity between 2-AP and other bioactive phenylpropanoids, the present research aims at evaluating the antioxidant, antinociceptive, and anti-inflammatory potential of 2-AP in silico, in vitro , and in vivo . At 30 min prior to the start of in vivo pharmacological testing, administration of 2-AP (25, 50, 75, and 100 mg/kg i.p.), morphine (6 mg/kg i.p.), dexamethasone (2 mg/kg s.c.), or vehicle alone was performed. In the acetic acid-induced abdominal writhing tests, pretreatment with 2-AP significantly reduced the number of abdominal writhes, as well as decreased licking times in the glutamate and formalin tests. Investigation of the mechanism of action using the formalin model led to the conclusion that the opioid system does not participate in its activity. However, the adenosinergic system is involved. In the peritonitis tests, 2-AP inhibited leukocyte migration and reduced releases of proinflammatory mediators TNF- α and IL-1 β . In vitro antioxidant assays demonstrated that 2-AP presents significant ability to sequester superoxide radicals. In silico docking studies confirmed interaction between 2-AP and the adenosine A2a receptor through hydrogen bonds with the critical asparagine 253 residues present in the active site. Investigation of 2-AP demonstrated its nociception inhibition and ability to reduce reactive oxygen species. Its interaction with A2a receptors may well be related to proinflammatory cytokines TNF- α and IL-1 β reduction activity, corroborating its antinociceptive effect.
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- 2019
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6. Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses.
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Luna EC, Luna IS, Scotti L, Monteiro AFM, Scotti MT, de Moura RO, de Araújo RSA, Monteiro KLC, de Aquino TM, Ribeiro FF, and Mendonça FJB
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- Animals, Oils, Volatile pharmacology, Arboviruses pathogenicity, Neglected Diseases therapy, Oils, Volatile therapeutic use
- Abstract
The term neglected diseases refers to a group of infections caused by various classes of pathogens, including protozoa, viruses, bacteria, and helminths, most often affecting impoverished populations without adequate sanitation living in close contact with infectious vectors and domestic animals. The fact that these diseases were historically not considered priorities for pharmaceutical companies made the available treatments options obsolete, precarious, outdated, and in some cases nonexistent. The use of plants for medicinal, religious, and cosmetic purposes has a history dating back to the emergence of humanity. One of the principal fractions of chemical substances found in plants are essential oils (EOs). EOs consist of a mixture of volatile and hydrophobic secondary metabolites with marked odors, composed primarily of terpenes and phenylpropanoids. They have great commercial value and were widely used in traditional medicine, by phytotherapy practitioners, and in public health services for the treatment of several conditions, including neglected diseases. In addition to the recognized cytoprotective and antioxidative activities of many of these compounds, larvicidal, insecticidal, and antiparasitic activities have been associated with the induction of oxidative stress in parasites, increasing levels of nitric oxide in the infected host, reducing parasite resistance to reactive oxygen species, and increasing lipid peroxidation, ultimately leading to serious damage to cell membranes. The hydrophobicity of these compounds also allows them to cross the membranes of parasites as well as the blood-brain barrier, collaborating in combat at the second stage of several of these infections. Based on these considerations, the aim of this review was to present an update of the potential of EOs, their fractions, and their chemical constituents, against some neglected diseases, including American and African trypanosomiasis, leishmaniasis, and arboviruses, specially dengue.
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- 2019
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7. Computational Studies Applied to Flavonoids against Alzheimer's and Parkinson's Diseases.
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Monteiro AFM, Viana JO, Nayarisseri A, Zondegoumba EN, Mendonça Junior FJB, Scotti MT, and Scotti L
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- Databases, Factual, Humans, Models, Molecular, Protein Conformation, Quantitative Structure-Activity Relationship, Alzheimer Disease drug therapy, Computer Simulation, Flavonoids therapeutic use, Molecular Docking Simulation, Neuroprotective Agents therapeutic use, Parkinson Disease drug therapy
- Abstract
Neurodegenerative diseases, such as Parkinson's and Alzheimer's, are understood as occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several natural products such as flavonoids have been reported in the literature for having the capacity to cross the blood-brain barrier and slow the progression of such diseases. The present article reports on in silico enzymatic target studies and natural products as inhibitors for the treatment of Parkinson's and Alzheimer's diseases. In this study we evaluated 39 flavonoids using prediction of molecular properties and in silico docking studies, while comparing against 7 standard reference compounds: 4 for Parkinson's and 3 for Alzheimer's. Osiris analysis revealed that most of the flavonoids presented no toxicity and good absorption parameters. The Parkinson's docking results using selected flavonoids as compared to the standards with four proteins revealed similar binding energies, indicating that the compounds 8-prenylnaringenin, europinidin, epicatechin gallate, homoeriodictyol, capensinidin, and rosinidin are potential leads with the necessary pharmacological and structural properties to be drug candidates. The Alzheimer's docking results suggested that seven of the 39 flavonoids studied, being those with the best molecular docking results, presenting no toxicity risks, and having good absorption rates (8-prenylnaringenin, europinidin, epicatechin gallate, homoeriodictyol, aspalathin, butin, and norartocarpetin) for the targets analyzed, are the flavonoids which possess the most adequate pharmacological profiles.
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- 2018
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8. Modulation of Drug Resistance in Staphylococcus aureus with Coumarin Derivatives.
- Author
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de Araújo RS, Barbosa-Filho JM, Scotti MT, Scotti L, da Cruz RM, Falcão-Silva Vdos S, de Siqueira-Júnior JP, and Mendonça-Junior FJ
- Abstract
Semisynthetic and commercial coumarins were investigated for their antibacterial and adjuvant properties with antibiotic agents against norfloxacin, erythromycin, and tetracycline resistant Staphylococcus aureus as based on efflux mechanisms. The coumarins and certain commercial antibiotics had their Minimum Inhibitory Concentrations determined by broth microdilution assay against resistant S. aureus strains which overexpress efflux pump proteins. For evaluation of the modulatory activity, the antibiotics MICs were determined in the presence of the coumarin derivatives at subinhibitory concentration. Although the coumarins did not display relevant antibacterial activity (MIC ≥ 128 µg/mL), they did modulate the antibiotics activities. Various coumarins, especially the alkylated derivatives in combination with antibiotics at subinhibitory concentrations, modulated antibiotic activity, reducing the MIC for tetracycline and norfloxacin by 2 to 8 times. Polar Surface Area (PSA) studies were performed and the fact that the presence of apolar groups is an important factor for the modulatory activity of coumarins was corroborated. Docking on the Penicillin-Binding Protein from MRSA identified that 18 is a potential ligand presenting low E binding. The results indicate that coumarin derivatives modulated antibiotic resistance and may be used as potential antibiotic adjuvants, acting by bacterial efflux pump inhibition in S. aureus.
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- 2016
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