1. Developmental Dynamics of Rett Syndrome
- Author
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Abhishek Banerjee, Danielle A. Feldman, Mriganka Sur, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Feldman, Danielle Angela, Banerjee, Abhishek, and Sur, Mriganka
- Subjects
0301 basic medicine ,Epigenetics of autism ,Rett syndrome ,Review Article ,Biology ,Synaptic Transmission ,Epigenesis, Genetic ,MECP2 ,lcsh:RC321-571 ,03 medical and health sciences ,0302 clinical medicine ,Cell Movement ,Neuroplasticity ,Rett Syndrome ,medicine ,Animals ,Humans ,Epigenetics ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Neuronal Plasticity ,Neurogenesis ,Brain ,medicine.disease ,Phenotype ,Developmental dynamics ,030104 developmental biology ,Neurology ,Neurology (clinical) ,Neuroscience ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
Rett Syndrome was long considered to be simply a disorder of postnatal development, with phenotypes that manifest only late in development and into adulthood. A variety of recent evidence demonstrates that the phenotypes of Rett Syndrome are present at the earliest stages of brain development, including developmental stages that define neurogenesis, migration, and patterning in addition to stages of synaptic and circuit development and plasticity. These phenotypes arise from the pleotropic effects of MeCP2, which is expressed very early in neuronal progenitors and continues to be expressed into adulthood. The effects of MeCP2 are mediated by diverse signaling, transcriptional, and epigenetic mechanisms. Attempts to reverse the effects of Rett Syndrome need to take into account the developmental dynamics and temporal impact of MeCP2 loss., National Institutes of Health (U.S.), Simons Foundation
- Published
- 2015