1. Antiproliferative Activity Evaluation of a Series of N-1,3-Benzothiazol-2-ylbenzamides as Novel Apoptosis Inducers
- Author
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Nicolino De Laurentis, Alessia Carocci, Fulvio Loiodice, Antonio Laghezza, Marilena Muraglia, Alessia Catalano, Filomena Corbo, Vincenzo Pagliarulo, Patrizia Ancona, Domenico Armenise, and Carlo Franchini
- Subjects
Human liver ,Article Subject ,010405 organic chemistry ,Cell growth ,Chemistry ,Cancer ,General Chemistry ,medicine.disease ,01 natural sciences ,0104 chemical sciences ,lcsh:Chemistry ,010404 medicinal & biomolecular chemistry ,lcsh:QD1-999 ,Apoptosis ,Cell culture ,Hepatocellular carcinoma ,Immunology ,Cancer research ,medicine ,Inducer ,skin and connective tissue diseases ,Inhibitory effect - Abstract
A series ofN-1,3-benzothiazol-2-ylbenzamide derivatives were studied for their antiproliferative activity on human liver hepatocellular carcinoma (HepG2) and human breast cancer (MCF-7) cell lines. Most of them were found to show a prominent inhibitory effect on cell growth. Among the most active compounds,1kemerged for its proapoptotic effect that is particularly evident towards MCF-7 cancer cell lines.
- Published
- 2016
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