1. Efficacy of Electroconvulsive Therapy in Bipolar Disorder with Mixed Features
- Author
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M. Palma, Bruno Trancas, Céu Monteiro, Nuno Borja-Santos, B. Ferreira, Graça Cardoso, Centro de Estudos de Doenças Crónicas (CEDOC), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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medicine.medical_specialty ,Pediatrics ,Mixed states ,Referral ,Article Subject ,lcsh:RC435-571 ,Bipolar disorder ,medicine.medical_treatment ,lcsh:BF1-990 ,MEDLINE ,behavioral disciplines and activities ,03 medical and health sciences ,0302 clinical medicine ,Electroconvulsive therapy ,SDG 3 - Good Health and Well-being ,Mixed affective state ,lcsh:Psychiatry ,mental disorders ,medicine ,In patient ,Psychiatry ,Terapêutica electroconvulsiva ,business.industry ,Perturbação bipolar ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,lcsh:Psychology ,Psychopharmacology ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Research Article - Abstract
BACKGROUND: The aim of this study was to investigate the effectiveness of electroconvulsive therapy (ECT) in medication-nonresponsive patients with mixed mania and bipolar depression. METHOD: Forty-one patients with mixed mania (DSM-IV diagnosis of bipolar I disorder, most recent episode mixed) and 23 patients with bipolar depression (DSM-IV diagnosis of bipolar I disorder, most recent episode depressed) consecutively assigned to ECT treatment were included in this study. Subjects were evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions-Severity of Illness scale (CGI-S). Assessments were carried out the day before starting ECT, 48 hours after completion of the third session (T1), and a week after the last session of ECT (T2). RESULTS: Both groups received an equal number of ECT sessions (mean +/- SD = 7.2 +/- 1.7 vs. 7.3 +/- 1.6). In both groups, within-group comparisons showed that there was a significant reduction in CGI-S score (mixed mania, p
- Published
- 2016
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