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Human skin is an efficient barrier that protects the organism from noxious substances. Wounds destroy this barrier. Wound healing is a phased physiological regeneration of the destroyed tissue that ideally leads to occlusion of a wound, in particular by regeneration of connective tissue and capillaries. The Wnt signaling pathway is a highly conserved signal transduction cascade across the animal kingdom that controls basic cellular interactions in multicellular organisms. Accordingly, through the Wnt signaling path many processes, e. g. as the balance between proliferation and differentiation or apoptosis, coordinated. Wnt signaling is activated by a wound and participates in each subsequent phase of the healing process, beginning with inflammatory control and programmed cell death, to the mobilization of stem cells within the wound. Endogenous Wnt signaling is an attractive therapeutic approach to assist in the repair of skin wounds, as the complex mechanisms of the Wnt signaling pathway have become increasingly understood over the years. This review summarizes current data to clarify the role of Wnt signaling in the wound healing process of the skin., Competing Interests: Die Autoren erklären, dass kein finanzieller Interessenskonflikt besteht. Der Inhalt des Artikels wurde ausschließlich von den gelisteten Autoren geschrieben. KSH, CT, BP, DP, DD, SR, GR, GG, LKB, FS, ML und ASY haben keinen Interessenskonflikt, keine Bindung oder finanzielle Beteiligung an eine Organisation mit finanziellem Interesse oder Konflikt mit dem behandelten Thema oder hier diskutierten Materialien., (© Georg Thieme Verlag KG Stuttgart · New York.)

Competing Interests: Disclosure The authors report no conflicts of interest in this work.

Background: Due to the loss of the natural skin barrier function with reduced immune competence as a result of a plasma loss and the numerous intensive care interventions, burn patients are particularly at risk for infection., Study Design: systematic review METHODS: A systematic review of German and English literature between 1990 and 2018 analyzes the epidemiological and diagnostic aspects as well as the therapeutic use of antibiotics in infections of burn patients in clinical trials., Results: A total number of 53 randomized controlled clinical trials met the inclusion criteria. Various types / forms of application of antibiotic prophylaxis in burn wounds were investigated: topically, systemically (generally), systemically (perioperatively), nonabsorbable antibiotics (= selective intestinal decontamination), locally (inhaled) and all forms of administration versus control. Early postburn prophylaxis was studied in low-severity patients (six studies) and severe burn patients (seven studies). Antimicrobial prophylaxis has shown no effectiveness in the prevention of toxic shock syndrome in low grade burns, but can be useful in patients with severe burns in need for mechanical ventilation. Perioperative prophylaxis has been studied in ten studies., Conclusion: The benefit of long-term systemic antibiotic prophylaxis in the majority of burn patients is not evident. Mild infections in stable clinical conditions should be closely monitored, while in severe infections, international sepsis guidelines and the Tarragona principle are recommended., Competing Interests: Die Autoren erklären, dass kein finanzieller Interessenskonflikt besteht. Der Inhalt des Artikels wurde ausschließlich von den gelisteten Autoren geschrieben. KSH, CT, DD, CW, AS, SR, DP, GR, KW, GG, LKB, FS, BB und ML haben keinen Interessenskonflikt, keine Bindung oder finanzielle Beteiligung an eine Organisation mit finanziellem Interesse oder Konflikt mit dem behandelten Thema oder hier diskutierten Materialien.No competing financial interest exists. The content of this article was expressly written by the authors listed. KSH, CT, DD, CW, AS, SR, DP, GR, KW, GG, LKB, FS, BB and ML have no potential conflicts of interest, affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed herein., (© Georg Thieme Verlag KG Stuttgart · New York.)