1. Treatment of non-fluctuating progressive dystonia: a neuropharmacological approach.
- Author
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Willemse J, van Nieuwenhuizen O, Gooskens RH, and Westenberg HG
- Subjects
- Adolescent, Child, Chromatography, High Pressure Liquid, Dystonia cerebrospinal fluid, Dystonia genetics, Female, Humans, Male, Syndrome, Basal Ganglia drug effects, Dystonia drug therapy, Homovanillic Acid cerebrospinal fluid, Hydroxyindoleacetic Acid cerebrospinal fluid, Levodopa therapeutic use, Phenylacetates cerebrospinal fluid, Synaptic Transmission drug effects
- Abstract
HVA and 5-HIAA in CSF were determined in five patients with non-fluctuating progressive dystonia before and after treatment with L-Dopa. The response to L-Dopa was unequivocally favourable in one patient. The HVA-level in her CSF was significantly reduced before treatment, whereas in the other four non-responding patients the pre-treatment HVA was normal. It is postulated, that the biochemical delineation of clinical responsiveness to a neurotransmitter may provide useful clues towards the classification of extrapyramidal disease in childhood.
- Published
- 1984
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