3 results on '"Manavoğlu, Osman"'
Search Results
2. Prognostic value of nm23 in gastrointestinal stromal tumors
- Author
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Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı., Kanat, Ozkan, Adım, Şaduman, Evrensel, Türkkan, Yerci, Ömer, Ediz, Bülent, Kurt, Ender, Demiray, Mutlu, Gönüllü, Güzin, Arslan, Murat, Manavoğlu, Osman, AAJ-1027-2021, M-8060-2019, and AAH-3847-2021
- Subjects
Adult ,Male ,Gastrointestinal ,Nucleoside diphosphate kinase A ,Clinical article ,Mitosis ,Expression ,Follow-up studies ,nm23 ,Article ,Tumor markers, biological ,Metastasis ,Association ,Nucleoside-Diphosphate Kinase ,Prunes ,Gastrointestinal stromal tumors ,Humans ,Tumor volume ,Tumor suppressor gene ,Middle aged ,Evaluation ,Stromal cells ,Aged ,Priority journal ,Nucleoside-diphosphate kinase ,Progression ,Proteins ,Prognosis ,Gastrointestinal neoplasms ,Immunohistochemistry ,Cancer survival ,Logistic models ,Retrospective studies ,Oncology ,Multivariate analysis ,Stromal tumor ,Protein expression ,Female ,Gene expression ,Controlled study ,Human - Abstract
Aim/Background: nm23 is suggested to represent a new class of metastasis suppressor genes. An inverse correlation between nm23 expression level and metastatic potential has been demonstrated in different malignancies. This study evaluated the prognostic value of nm23 in gastrointestinal stromal tumors (GISTs). Methods: Imummohistochemical expression level of nm23 was studied in a total of 32 patients with localized GISTs. The relationship between the expression level of nm23 and patient outcome was investigated. Results: A tumor size of 10 cm or more and a mitotic rate of 10 or more per 50 high-power fields were not significantly associated with the metastasis risk (p = 0.60 and 0.55, respectively). Tumors with high expression of nm23 tended to have significantly lower metastatic potential (p = 0.02). The median survival was significantly longer in patients with high expression of nm23 (p = 0.007). Conclusion: These results suggest that expression level of nm23 may be considered as a prognostic predictor in GISTs. Future studies with larger patient numbers will be essential to confirm the prognostic significance of nm23 in patients with GIST.
- Published
- 2004
3. Protective effect of amifostine against toxicity of paclitaxel and carboplatin in non-small cell lung cancer - A single center randomized study
- Author
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Turkkan Evrensel, Mutlu Demiray, Hakan Coskun, Ozkan Kanat, İbrahim Baran, Osman Manavoglu, Ender Kurt, Guzin Gonullu, Mehmet Zarifoglu, Ömer Faruk Turan, Uludağ Üniversitesi/Tıp Fakültesi/Medikal Onkoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun ve Boğaz Hastalıkları Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı., Kanat, Özkan, Evrensel, Türkkan, Baran, İbrahim, Coşkun, H. Hakan, Zarifoğlu, Mehmet, Turan, Ömer Faruk, Kurt, Ender, Demiray, Mutlu, Gönüllü, Güzin, Manavoğlu, Osman, AAJ-1027-2021, and M-8060-2019
- Subjects
Oncology ,Male ,Cancer Research ,Heart diseases ,medicine.medical_treatment ,Sinus bradycardia ,Randomization ,Trial ,Agent ,Dexamethasone ,Carboplatin ,chemistry.chemical_compound ,Tinnitus ,Patient selection ,Lung neoplasms ,Controlled clinical trial ,1-hour ,Protective agents ,Deterioration ,Disease course ,Prospective cohort study ,Middle aged ,Priority journal ,Protection ,Anemia ,Hematology ,General Medicine ,Amifostine ,Blood toxicity ,Clinical trial ,Damage ,Diphenhydramine ,Lung non small cell cancer ,Randomized controlled trial ,Combination ,Vertigo ,Female ,Cancer chemotherapy ,medicine.symptom ,Hypotension ,medicine.drug ,Drug hypersensitivity ,Human ,Adult ,medicine.medical_specialty ,Neutropenia ,Paclitaxel ,Vomiting ,Clinical article ,Pemetrexed ,Non-Small Cell Lung Carcinoma ,Ranitidine ,Article ,Ototoxicity ,Internal medicine ,Antineoplastic combined chemotherapy protocols ,medicine ,Neurotoxicity ,Humans ,Cisplatin plus vinorelbine ,Heart ventricle extrasystole ,Paresthesia ,Infusion ,Lung cancer ,Disease severity ,Chemotherapy ,Toxicity ,business.industry ,Motor dysfunction ,Hematologic diseases ,Hearing loss ,Carcinoma, non-small-cell lung ,Heart function ,medicine.disease ,Nervous system diseases ,Thrombocytopenia ,Cardiotoxicity ,Drug effect ,chemistry ,Cytoprotection ,Phase-II ,business ,Antiemetic agent ,Head ,Prospective studies ,Controlled study ,Sensory dysfunction - Abstract
Aim: In this study we determined the protective role of amifostine against the side effects of the combination of paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). Patients and Methods: Chemo-naive patients with NSCLC were eligible. Thirty-eight patients were randomized to receive paclitaxel 175 mg/m2 and carboplatin AUC=6 with amifostine 910 mg/m2 (group B) or chemotherapy alone (group A). The occurrences of hematologic, neurologic, cardiologic toxicities, and ototoxicity were evaluated. Results: All patients completed the six scheduled cycles of therapy. A total of 114 cycles of chemotherapy was given in both groups. Neutropenia grade 3–4 was observed in 11 cycles (9.6%) in group A and 19 cycles (16.6%) in group B (p=0.16). Paresthesia grade 1 or 2 was observed in 18 of 19 patients of group A and in 8 of 19 patients of group B, following the sixth cycle of chemotherapy (p=0.018). Two patients of group B and nine patients of group A suffered from sensory motor impairment grade 2 (p=0.029). There was no clinical evidence in any patient for deterioration in cardiac function. Asymptomatic and transient sinus bradycardia or ventricular premature beats developed in four patients. None of the patients reported vertigo, tinnitus, or hearing loss. Conclusion: The addition of the amifostine to the combination of paclitaxel and carboplatin may prevent or reduce the incidence of neurotoxicity in the treatment of NSCLC. Amifostine does not appear to have a preventive role in neutropenia.
- Published
- 2003
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