1. Ischemia–Reperfusion Injury of the Mouse Kidney
- Author
-
Leif Oxburgh and Mark P. de Caestecker
- Subjects
Kidney ,business.industry ,Ischemia ,Injury and repair ,Bioinformatics ,medicine.disease ,medicine.anatomical_structure ,Tissue Harvesting ,Acute injury ,Mouse Kidney ,Medicine ,business ,Reperfusion injury ,Blood sampling - Abstract
Studies of the complex responses of the kidney to acute injury have yielded important insights into mechanisms of tissue injury and repair. A variety of injury models have contributed to this impressive body of knowledge, but the ischemia-reperfusion (IR) model has perhaps been the most widely used. This chapter contains a detailed method description for IR injury in the mouse together with notes on blood sampling and tissue harvesting. The aim of the chapter is to provide the novice with a step-by-step guide to establishing this procedure in their research program.
- Published
- 2012
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