1. Expression of gamma delta T lymphocytes derived from human intestinal biopsies.
- Author
-
Volk BA, Niessner M, Amann B, Fauser AA, and Gerok W
- Subjects
- Cell Separation, Cells, Cultured, Humans, Inflammatory Bowel Diseases immunology, Inflammatory Bowel Diseases pathology, Mycobacterium tuberculosis immunology, Phytohemagglutinins immunology, Intestinal Mucosa cytology, Intestinal Mucosa immunology, Receptors, Antigen, T-Cell, gamma-delta, T-Lymphocytes cytology, T-Lymphocytes immunology
- Abstract
Although most T cells express the alpha/beta TCR, the gamma/delta TCR is expressed only on a small percentage of peripheral lymphocytes and CD3+ intestinal T cells. The most striking feature is a wide variation in the proportion of gamma/delta+ T cells in freshly isolated peripheral blood cells from normal individuals and patients with IBD. The augmentation of the gamma/delta+ T cell subpopulation derived from human intestinal biopsies after repeated stimulation with MT, even in the absence of filler cells, suggests that gamma/delta+ cells from human gut mucosa may play a role in generating a primary immune response to MT.
- Published
- 1991
- Full Text
- View/download PDF