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[Objective] This study aimed to investigate the effective prevention and control of maize rough dwarf disease in different areas with varying epidemic intensity in Shandong Province. [Method] Control effects of single application of virus inhibitors and composite application of virus inhibitors with seed dressing agents and pesticides on maize rough dwarf disease in different areas with varying epidemic intensity were investigated. [Result] The same treatment possessed entirely different effects in severely affected areas and slightly affected areas. To be specific, single application of virus inhibitors in slightly affected areas exhibited good control effects, with a control efficiency of 76.59% and yield increment rate of 158.21%; in severely affected areas, single application of virus inhibitors led to low control efficiency and yield increment rate. The highest control efficiency of composite application of virus inhibitors with seed dressing agents and pesticides in severely affected areas was 71.38%, and experimental plots changed from total crop failure to have certain economic output. [Conclusion] In different areas with varying epidemic intensity of maize rough dwarf disease, different application modes should be adopted according to local conditions, thereby saving cost and improving control efficiency. [ABSTRACT FROM AUTHOR]