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Limited-angle CT is a challenging problem in real applications. Incomplete projection data will lead to severe artifacts and distortions in reconstruction images. To tackle this problem, we propose a novel reconstruction framework termed Deep Iterative Optimization-based Residual-learning (DIOR) for limited-angle CT. Instead of directly deploying the regularization term on image space, the DIOR combines iterative optimization and deep learning based on the residual domain, significantly improving the convergence property and generalization ability. Specifically, the asymmetric convolutional modules are adopted to strengthen the feature extraction capacity in smooth regions for deep priors. Besides, in our DIOR method, the information contained in low-frequency and high-frequency components is also evaluated by perceptual loss to improve the performance in tissue preservation. Both simulated and clinical datasets are performed to validate the performance of DIOR. Compared with existing competitive algorithms, quantitative and qualitative results show that the proposed method brings a promising improvement in artifact removal, detail restoration and edge preservation. [ABSTRACT FROM AUTHOR]