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Neurotransmitter sensing is currently a challenge in biomedical research, and optoelectronic sensing may play an important role in this field. In particular, miniature visible-light photo-spectrometers can be very useful for molecular detection. In this respect, this work evaluates a new type of spectrometer geometry based on the grism, or grating-prism, which combines an optical grating and an optical prism. The system was first designed in either transmission or reflection geometry, and then adapted to fit commercially available components so that a prototype could be fabricated in the laboratory. The comparison with a more conventional approach shows that the grism-based spectrometer offers superior resolution as well as a smaller footprint.

Neurotransmitter sensing is an importance component of biomedical research, and optoelectronic sensors play an important role in it. In particular, visible-light photo-spectrometers can be very useful for molecular detection and measurement. This work evaluates two optical design modes for the conception of a Czerny- Turner spectrometer. The system was designed at first using the non-sequential mode and then remade using the sequential mode. By comparing the same design made using both modes, the sequential mode had shown superior optimization potential.

Neurotransmitter sensing is essential in biomedical research to understand brain behavior, with Optical sensing useful for passive measurements. For instance, visible-light spectrophotometry can be used to detect and measure neurotransmitter concentrations in liquid. An important part of the process is the prediction of molecule concentration from the measured data. This work describes an FPGA-based system to measure neurotransmitter concentration in a multi-sensor platform, using a visible-light optical spectrometer and a simple regression predictor. The design required very few hardware resources and it was tested on dopamine data with excellent results.