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MEMS initiator has been developed rapidly for its low detonating power and small volume. MEMS metal bridge as one type of the MEMS initiators, which has the same process with ASIC (Application-specific integrated circuit). In this paper, one novel ASIC self-destruction technology in chip level mainly based on MEMS metal bridge initiator is presented. A typical experimental structure was designed. Based on this structure, a simulation model was built. Through the simulation, when the MEMS metal bridge made by proper material was excited by pulse current, the circuits of the ASIC could be destroyed immediately because of the electric blasting produced by excited metal bridge. The conclusion was that the self-destruction technology can achieve the self-destruction of ASIC in chip level.