1. Steady-State and Transient Performance of Ion-Sensitive Electrodes Suitable for Wearable and Implantable Electro-Chemical Sensing.
- Author
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Jin, Xin, Saha, Ajanta, Jiang, Hongjie, Oduncu, Muhammed Ramazan, Yang, Qingyu, Sedaghat, Sotoudeh, Maize, Kerry, Allebach, Jan P., Shakouri, Ali, Glassmaker, Nicholas, Wei, Alexander, Rahimi, Rahim, and Alam, Muhammad A.
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ELECTRODE performance , *STEADY-state responses , *PRECISION farming , *CELLULAR signal transduction - Abstract
Traditional Potentiometric Ion-selective Electrodes (ISE) are widely used in industrial and clinical settings. The simplicity and small footprint of ISE have encouraged their recent adoption as wearable/implantable sensors for personalized healthcare and precision agriculture, creating a new set of unique challenges absent in traditional ISE. In this paper, we develop a fundamental physics-based model to describe both steady-state and transient responses of ISE relevant for wearable/implantable sensors. The model is encapsulated in a “generalized Nernst formula” that explicitly accounts for the analyte density, time-dynamics of signal transduction, ion-selective membrane thickness, and other sensor parameters. The formula is validated numerically by self-consistent modeling of multispecies ion-transport and experimentally by interpreting the time dynamics and thickness dependence of thin-film solid-contact and graphene-based ISE sensors for measuring soil nitrate concentration. These fundamental results will support the accelerated development of ISE for wearable/implantable applications. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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