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The expeditious development in cloud-enabled industrial Internet of Things (IIoT) healthcare has significantly reduced the costs to monitor and protect people at home while notably improving the quality of human healthcare. Despite its considerable convenience and benefits, it confronts some security and privacy challenges in the aspects of bilateral fine-grained access control, the authenticity and tamper resistance of shared health data. To tackle these constraints, a secure privacy-preserving bilateral access control scheme with fine granularity (PBAC-FG) is proposed in this article. Our PBAC-FG exploits fine-grained access control and matchmaking encryption technologies to ensure both participants (e.g., patients and healthcare providers) can specify their respective fine-grained access control over the encrypted health data, such that only authorized counterparts can efficiently access the health data. Besides, the correct rigorous security proofs are indicated to verify that our PBAC-FG is indeed secure. We carry out comprehensive performance evaluations and comparisons to demonstrate the efficiency and practicality of the PBAC-FG for IIoT healthcare applications. [ABSTRACT FROM AUTHOR]

Aiming for minimizing passengers’ waiting time and vehicles’ vacancy rate, online car-hailing service systems with fog computing has been deployed in various scenarios. In this paper, we focus on addressing the security and privacy issues in such a promising system by customizing a new cryptographic primitive to provide the following security guarantees: (1) private, fine-grained and bilateral order matching between passengers and drivers; (2) authenticity verification of passengers’ orders in the form of ciphertext, and (3) temporal assurance of passengers’ ciphertext orders. To the best of our knowledge, no previous system has been designed to meet all three requirements. Existing cryptographic primitives (including forward/puncturable encryption (FE/PE) and attribute based matchmaking encryption (AB-ME)) may be leveraged to partially address some of challenges, but there lacks a comprehensive solution. Moreover, the integration of existing works is hampered by the heterogeneity and the weak coupling between distinct cryptographic primitives. As a result, it is infeasible to directly exploit them for the online car-hailing service. To tackle that, we put forward a new cryptographic primitive called Fine-grained Puncturable Matchmaking Encryption (FP-ME) by modifying AB-ME and incorporating PE technology. FP-ME can simultaneously implement fine-grained and bilateral order matching, the authenticity of passengers’ orders, and meeting the time constraint of passengers’ orders. We formalize the adversarial models for the proposed FP-ME and then present rigorous security analysis to prove the security of the proposed system. Additionally, we study performance of the system via simulations to demonstrate its practicability and effectiveness in the real-world applications. [ABSTRACT FROM AUTHOR]

Vehicular social networks (VSNs) have emerged as the promising paradigm of vehicular networks that can improve traffic safety, relieve traffic congestion and even provide comprehensive social services by sharing vehicular sensory data. To selectively share the sensory data with other vehicles in the vicinity and reduce the local storage burden of vehicles, the vehicular sensory data are usually outsourced to vehicle cloud server for sharing and searching. However, existing data sharing systems for VSNs can neither provide secure selective one-to-many data sharing and verifiable data retrieval over encrypted data nor ensure that the integrity of retrieved data. In this paper, we propose FTDS, a secure flexible and tampering-resistant data sharing system for VSNs by introducing a novel secure key-aggregate search encryption scheme and a tampering-resistant blockchain technology. With the proposed FTDS system for VSNs, the vehicular sensory data can be selectively shared and retrieved in a fine-grained way. Besides, our system allows vehicle data users to detect any unauthorized manipulation. Then, we present the detailed security analysis to prove that the proposed data sharing system can achieve both selective security and verifiability. We also evaluate its performance and demonstrate that it is efficient and practical for the VSNs scenarios. [ABSTRACT FROM AUTHOR]

Objective: Targeting in vivo has been a spotlight for precise medicine. Multiple strategies have been proposed for this issue. However, the efficiency of solely biochemical strategies currently remains to be improved. It has been thought that external field-guided targeting will be a beneficial supplement for the passive and the active targeting. Methods: Here, we focused on the magnetic field-guided targeting of magnetized erythrocytes, discovering that a focused magnetic field can direct aggregation of magnetic erythrocytes into a specific region in vivo. Results: The systematic investigation about the aggregates in cerebral vessels showed that the aggregates were isotropic and able to stably exist for six hours. The formation of cellular aggregates can alter echoing characteristic of the blood vessels meaning the vascular wall became more rigid. If the erythrocytes were repeatedly directed into aggregation in an identical region, a stable plaque of erythrocytes can form, which can mimic the process of thrombosis. Significance: We believe these results will be beneficial to the development of novel engineered strategy for targeted delivery of drugs and modeling of vascular diseases. [ABSTRACT FROM AUTHOR]

With the significant rise in the demand for infinite storage resource and high-quality retrieval service, cloud computing is deemed to be a highly remarkable technology. For privacy concerns, several research works on ranked multi-keyword search over the encrypted cloud data under multiple data owner model have been developed. However, most of these schemes are vulnerable to keyword guessing attacks and equivalence test attack. Besides, they cannot accurately return the top- $k$ ranked search results from the encrypted data of different data owners to the data users. Obviously, these drawbacks may incur leakage of privacy-sensitive keyword information and the inaccuracy of returned search results. Therefore, in this article, we first propose a novel efficient ranked multi-keyword retrieval scheme with keyword privacy for multiple data owners, which empowers the cloud server to perform multi-keyword search over the cloud data and then, return the top- $k$ ranked search results to data users without leaking any keyword and trapdoor information. Additionally, we show through rigorous security analysis that our scheme is secure against the attacks launched by inside attackers and outside attackers. Finally, the performance evaluation indicates that our scheme has more satisfactory features than the existing ranked multi-keyword search schemes. [ABSTRACT FROM AUTHOR]

Objective: The interaction between superparamagnetic iron oxide (SPIO) nanoparticles and mesenchymal stem cells (MSCs) in the presence of pulsed magnetic field (PMF) has become an important area of research in recent years. Methods: A parameter-adjustable pulsed magnetic field was developed based on the principle of insulated gate bipolar translator transistor-controlled discharge of large capacitances. The internalizations of SPIO nanoparticles by MSCs were investigated under the treatment of PMF in both intermittent stimulation mode and continuous stimulation mode. Results: The intensities and frequencies of pulsed magnetic field can be adjustable in the range of 1.9–4.6 mT and 3–5 kHz, respectively. This PMF was safe to the MSCs. However, the uptake of SPIO nanoparticles by MSCs was significantly prohibited under the treatment of kHz-ranged PMF while the 10 Hz PMF enhanced the cellular uptake of nanoparticles. This phenomenon was relative with the magnetic effect of the PMF with different frequency. Conclusion: The PMF can be used to effectively regulate the cellular uptake of SPIO nanoparticles and the mechanism lies in the magnetic effect. Significance: The interaction between SPIO nanoparticles and the MSCs is a fundamental and important issue for nanomedicine and stem cell research. Our results demonstrate that the external magnetic field can be used to regulate their interaction. We believe that this safe, facile, and flexible method will greatly promote the development and clinical translation of regenerative medicine and nanomedicine. [ABSTRACT FROM AUTHOR]

The sharing of personal data with multiple users from different domains has been benefited considerably from the rapid advances of cloud computing, and it is highly desirable to ensure the sharing file should not be exposed to the unauthorized users or cloud providers. Unfortunately, issues such as achieving the flexible access control of the sharing file, preserving the privacy of the receivers, forming the receiver groups dynamically, and high efficiency in encryption/decryption still remain challenging. To deal with these challenges, we provide a novel anonymous attribute-based broadcast encryption (A $^{2}$ B $^{2}$ E) which features the property of hidden access policy and enables the data owner to share his/her data with multiple participants who are inside a predefined receiver set and fulfill the access policy. We first suggest a concrete A $^{2}$ B $^{2}$ E scheme together with the rigorous and formal security proof without the support of the random oracle model. Then, we design an efficient and secure data sharing system by incorporating the A $^{2}$ B $^{2}$ E scheme, verifiable outsourcing decryption technique for attribute-based encryption, and the idea of online/offline attribute-based encryption. Extensive security analysis and performance evaluation demonstrate that our data sharing system is secure and practical. [ABSTRACT FROM AUTHOR]

Objective: Cell inflammation process is reflected through real-time in situ cellular temperature changes. Methods: A wireless thermometry system for in situ cellular temperature measurements was used in an incubator to detect the HMEC-1 cellular temperature under lipopolysaccharide inflammation production and norepinephrine for inflammation repair. Combining the changes in cell viability, inflammatory factor levels, and ATP content caused by different lipopolysaccharide or norepinephrine doses, an obvious inflammatory response and a repair effect were obtained. Temperature variations were correlated with ATP content. Results: An obvious inflammatory response with a lipopolysaccharide concentration of 0.1 mg/L and an optimal repair effect with 1 μM norepinephrine were obtained. The relationship between temperature changes and ATP content were quite different during the production of inflammation in HMEC-1 cells, having an approximately linear relationship, while under conditions of inflammation repair in HMEC-1 cells, there was an obvious nonlinear relationship. Conclusion: During cell damage, cell thermogenesis has a linear correlation with intracellular energy. While during cell repair, there is a gradual saturation relationship between the temperature (small range) and ATP, which may be because the thermogenesis capacity of the cell is enhanced compared to conditions during cell energy storage. Additionally, there is an optimal drug concentration for cell action during cell injury and cell repair, which is not dose-dependent. Significance: Whether in inflammation production or treatment, there is an optimal drug concentration. The relationship between cell thermogenesis and intracellular energy reserves is related to cell processes. Quick analysis of the energy changes in different physiological process can be realized. [ABSTRACT FROM AUTHOR]

Objective: A wireless, multichannel system for real-time measurement of the cellular-temperature response to drugs is developed. Methods: The acquisition system applies a high-precision reference resistor and a low real-time measurement current (below or equal to 0.14 mA) to reduce self-heating via the intermittent measurement. Cells of a small volume cell medium are cultured on the surface of the platinum thermal resistor and subsequently measured in the incubator. Results: The resistance resolution of the circuit exhibits 20 mΩ, which corresponds to no more than 0.01 °C. The resistance deviations of each channel are corrected with software compensation. The linearity between the temperature and resistance of the sensors lies above 0.999 in the applied temperature range (30 °C–42 °C). Observations with the scanning electron microscope show that the cells grow well on the sensor surface. The latter is composed of a glass glaze, which is nontoxic for organisms. The cell population temperature measurements under norepinephrine action present an obvious temperature rise, which can be the result of the drug binding to the receptors on cell membrane thus promoting a cationic inflow. Conclusion: The platinum sensor and multichannel acquisition system can be used to determine the temperature changes of cells in their original state. Significance: The wireless, real-time, high-throughput temperature detection method is particularly suitable to evaluate the thermogenic ability of growing cells that interact with other matter or organisms. The proposed method can help to explore thermal changes in cell populations, intercellular connections, and social connections of cells. [ABSTRACT FROM AUTHOR]