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The unequal area facility layout problem (UA-FLP) is to place some objects in a specified space according to certain requirements, which is a NP-hard problem in mathematics because of the complexity of its solution, the combination explosion and the complexity of engineering system. Particle swarm optimization (PSO) algorithm is a kind of swarm intelligence algorithm by simulating the predatory behavior of birds. Aiming at the minimization of material handling cost and the maximization of workshop area utilization, the optimization mathematical model of UA-FLPP is established, and it is solved by the particle swarm optimization (PSO) algorithm which simulates the design of birds' predation behavior. The improved PSO algorithm is constructed by using nonlinear inertia weight, dynamic inertia weight and other methods to solve static unequal area facility layout problem. The effectiveness of the proposed method is verified by simulation experiments.