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1. [Non-steroidal anti-inflammatory agents. VI. Optically active 3-(4-biphenylyl)-3-oxybutyric, valerianic, caproic and isocaproic acids].

Author

Guarnieri A, Burnelli S, Varoli L, Barbaro AM, and Gaiardi M

Subjects
Animals, Caproates pharmacology, Carrageenan, Edema chemically induced, Edema physiopathology, Hydroxybutyrates pharmacology, Male, Pentanoic Acids pharmacology, Rats, Stereoisomerism, Anti-Inflammatory Agents chemical synthesis, Caproates chemical synthesis, Hydroxybutyrates chemical synthesis, Pentanoic Acids chemical synthesis, Valerates chemical synthesis
Abstract

The synthesis of the (+/-) 3-(4-biphenylyl)-3-hydroxybutanoic, pentanoic, hexanoic and isohexanoic acids, and their resolution in to enantiomers are described. The latter were submitted to preliminary assay for antiinflammatory activity: interesting results were obtained above all for the isohexanoic acid derivative.

Published
1978

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