31 results on '"Zecchin M"'
Search Results
2. Cardiac contractility modulation in heart failure with reduced ejection fraction: critical review of evidence and application perspectives [Modulazione della contrattilità cardiaca nello scompenso cardiaco a frazione di eiezione ridotta: revisione critica delle evidenze ed aspetti decisionali pratici]
- Author
-
Biffi M, Aspromonte N, Bongiorni MG, Clemenza F, D'Onofrio A, De Ferrari GM, Giallauria F, Grimaldi M, Oliva F, Senni M, Tondo C, Zecchin M, Cappannoli L, Giannotti Santoro M, Ziacchi M, Porcari A, Sinagra G, Biffi, M, Aspromonte, N, Bongiorni, M, Clemenza, F, D'Onofrio, A, De Ferrari, G, Giallauria, F, Grimaldi, M, Oliva, F, Senni, M, Tondo, C, Zecchin, M, Cappannoli, L, Giannotti Santoro, M, Ziacchi, M, Porcari, A, and Sinagra, G
- Subjects
Heart Failure ,Registrie ,Treatment Outcome ,Stroke Volume ,Myocardial Contraction ,Human - Abstract
This critical review illustrates the pathophysiological aspects and available scientific evidence about cardiac contractility modulation therapy. A useful algorithm dealing with the essential decisional knots to consider for device implantation in patients with heart failure in NYHA class >II and ejection fraction
- Published
- 2021
3. [The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Report 2022].
- Author
-
Proclemer A, Zecchin M, Zanotto G, Gregori D, De Ponti R, and D'Onofrio A
- Abstract
Background: The Pacemaker (PM) and Implantable Cardioverter-Defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the voluntary Italian collaborating centers., Methods: For the year 2022 main data about national PM and ICD implantation activity were obtained on the basis of European Cards and subsequently analyzed to create a standard report., Results: PM Registry: data about 17 800 PM implantations were collected (14 191 first implants and 3609 replacements). The number of collaborating centers was 152. Median age of treated patients was 81 years (75 quartile I; 86 quartile III). Main ECG indications included atrioventricular conduction disorders in 46.0% of first PM implants, sick sinus syndrome in 17.7%, atrial fibrillation plus bradycardia in 7.7%, other unspecified ECG and electrophysiological abnormalities in 43.0%. For first PM implants, pacing in DDDR mode was reported in 42.2%, followed by DDD mode (20.6%), VVIR mode (25.1%), VVI mode (11.1%) and finally VDD-VDDR (5.1%). Median value of longevity of explanted PMs was 8.3 years. ICD Registry: data about 5210 ICD implantations were obtained (3656 first implants and 1554 replacements). The number of collaborating centers was 301. Median age of treated patients was 72 years (63 quartile I; 79 quartile III). Primary prevention indication was reported in 72.4% of first implants, secondary prevention in 27.6% (cardiac arrest in 4.6% of records). A single-chamber ICD was used in 30.3% of first implants, dual-chamber ICD in 30.0% and biventricular ICD in 39.7%. Median value of longevity of explanted ICDs was 7.0 years., Conclusions: In the calendar year 2022, the Italian PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The ICD Registry documented a large use of prophylactic and biventricular ICDs, reflecting a favorable adherence in clinical practice to trials and guidelines. The ICD longevity and the number of recalls demonstrated a favorable trend.
- Published
- 2023
- Full Text
- View/download PDF
4. [The ECG as a "red flag" and potential prognostic predictor (2)].
- Author
-
Pezzato A, Zecchin M, and Sinagra G
- Subjects
- Humans, Prognosis, Electrocardiography
- Published
- 2023
- Full Text
- View/download PDF
5. [The Regional Registry of Sudden Cardiac Death of Friuli Venezia Giulia. Protocols, best practices and results of a multidisciplinary project].
- Author
-
D'Errico S, Bergamini PR, Fattorini P, Zanconati F, Bussani R, Cova MA, Pagnan L, Belgrano M, Gasparini P, Girotto G, Lenarduzzi S, Addobbati R, Rakar S, Aleksova A, Dal Ferro M, Zecchin M, and Sinagra G
- Subjects
- Humans, Middle Aged, Registries, Italy epidemiology, Death, Sudden, Cardiac epidemiology, Death, Sudden, Cardiac etiology, Death, Sudden, Cardiac prevention & control
- Abstract
With the regional law n. 26 of December 30, 2020, the Friuli Venezia Giulia Region wanted to promote the establishment of the Regional Register of Sudden Cardiac Death, with the aim of favoring the study of all those deaths that occurred suddenly and unexpectedly under the age of 50 years in which it is not possible to trace the cause of death with certainty. Such dramatic events, difficult to quantify considering the complexity of data collection, are often accepted with resignation without any further investigation of the possible causes. The Regional Register of Sudden Cardiac Deaths of Friuli Venezia Giulia was born from this premise and from the awareness of the importance of going back with a rigorous scientific methodology and through a multidisciplinary approach, to the diagnosis of hereditary heart diseases which, when determined, allow the enrollment of relatives in a cardiological screening process and, therefore, primary prevention of potentially fatal events. The authors describe the operating procedures feeding the Regional Register and present the results of the first year of activity on 26 cases.
- Published
- 2022
- Full Text
- View/download PDF
6. [Management of infections in patients with cardiac implantable electronic devices].
- Author
-
Nesti M, Calvanese R, Pignalberi C, Mascioli G, China P, Sgarito G, Bardari S, and Zecchin M
- Subjects
- Anti-Bacterial Agents therapeutic use, Consensus, Electronics, Humans, Defibrillators, Implantable adverse effects, Pacemaker, Artificial, Prosthesis-Related Infections drug therapy, Prosthesis-Related Infections etiology, Prosthesis-Related Infections prevention & control
- Abstract
Implantation of pacemakers and cardiac defibrillators is a life-saving treatment but can put our patients at risk of infections, increasing morbidity and mortality and prolonging hospitalization with a significant financial healthcare burden. A preventive strategy is crucial but, while several strategies such as administration of intravenous antibiotic therapy before implantation are well recognized, other uncertainties remain. The main gaps regard the use of periprocedural measures, including antibacterial envelope to prevent device infection, the appropriate management of antithrombotic therapy before and after device implantation and timing of device reimplantation. To address these issues, some important randomized clinical trials and a European Heart Rhythm Association consensus document have recently been published. The aim of this article is to review current knowledge on the management of infections in patients with cardiac implantable electronic devices to help not only electrophysiologists, but also physicians in their daily practice.
- Published
- 2022
- Full Text
- View/download PDF
7. [ANMCO Position paper: Care pathway for advanced heart failure patients candidate for heart transplantation/ventricular assist device].
- Author
-
Iacoviello M, Cipriani M, Valente S, Marini M, Ammirati E, Benvenuto M, Cassaniti LR, De Maria R, Gori M, Municinò A, Navazio A, Amodeo V, Aspromonte N, Barili F, Casolo G, Clemenza F, Di Eusanio M, Di Lenarda A, Di Tano G, Domenicucci S, Faggian G, Francese GM, Frongillo D, Gilardi R, Iacovoni A, Imazio M, Livi U, Maiello C, Milano A, Mondino M, Moreo AM, Mortara A, Murrone A, Palmieri V, Pelenghi S, Pini D, Pistono M, Porcu M, Potena L, Rinaldi M, Romanò M, Roncon L, Rossini R, Russo CF, Scotto di Uccio F, Urbinati S, Zecchin M, Caldarola P, Oliveti A, Frigerio M, Musumeci F, Gulizia MM, Oliva F, Gabrielli D, and Colivicchi F
- Subjects
- Cardiotonic Agents therapeutic use, Critical Pathways, Humans, Palliative Care, Heart Failure, Heart Transplantation, Heart-Assist Devices
- Abstract
Heart failure is a complex clinical syndrome with a severe prognosis, despite therapeutic progress. The management of the advanced stages of the syndrome is particularly complex in patients who are referred to palliative care as well as in those who are candidates for cardiac replacement therapy. For the latter group, a prompt recognition of the transition to the advanced stage as well as an early referral to the centers for cardiac replacement therapy are essential elements to ensure that patients follow the most appropriate diagnostic-therapeutic pathway. The aim of this document is to focus on the main diagnostic and therapeutic aspects related to the advanced stages of heart failure and, in particular, on the management of patients who are candidates for cardiac replacement therapy.
- Published
- 2022
- Full Text
- View/download PDF
8. [The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Report 2020].
- Author
-
Proclemer A, Zecchin M, Zanotto G, Gregori D, D'Onofrio A, Ricci RP, and De Ponti R
- Subjects
- Aged, Aged, 80 and over, Arrhythmias, Cardiac, Humans, Registries, Cardiac Resynchronization Therapy, Defibrillators, Implantable, Pacemaker, Artificial
- Abstract
Background: The Pacemaker (PM) and Implantable Cardioverter-Defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers., Methods: For the year 2020, the main data about national PM and ICD implantation activity were obtained on the basis of European Cards and subsequently analyzed to create a standard report., Results: PM Registry: data about 22 080 PM implantations were collected (18 027 first implants and 3803 replacements). The number of collaborating centers was 142. Median age of treated patients was 82 years (75 quartile I; 87 quartile III). ECG indications included atrioventricular conduction disorders in 31.0% of first PM implants, sick sinus syndrome in 13.8%, atrial fibrillation plus bradycardia in 9.9%, other unspecified ECG and electrophysiological abnormalities in 36.6%. Use of single-chamber PMs was reported in 29.0% of first implants, of dual-chamber PMs in 68.2%, of PM with cardiac resynchronization therapy (CRT) in 2.7%. ICD Registry: data about 11 931 ICD implantations were obtained (8266 first implants and 3665 replacements). The number of collaborating centers was 330. Median age of treated patients was 72 years [63 quartile I; 79 quartile III]. Primary prevention indication was reported in 85.0% of first implants, secondary prevention in 15.0% (cardiac arrest in 4.2%). A single-chamber ICD was used in 30.2% of first implants, dual-chamber ICD in 31.2% and biventricular ICD in 38.6%., Conclusions: In the calendar year 2020, the Italian PM Registry showed stable ECG and symptom indications, with an important prevalence of dual-chamber pacing. The ICD Registry documented a large use of prophylactic and biventricular ICDs, reflecting a favorable adherence in clinical practice to trials and guidelines. The ICD longevity and the number of recalls demonstrated a favorable trend. In order to increase and optimize the cooperation of Italian PM and ICD implanting centers, the online data entry (https://www.aiac.it/riprid) should be adopted at large scale.
- Published
- 2022
- Full Text
- View/download PDF
9. [Cardiac contractility modulation in heart failure with reduced ejection fraction: critical review of evidence and application perspectives].
- Author
-
Biffi M, Aspromonte N, Bongiorni MG, Clemenza F, D'Onofrio A, De Ferrari GM, Giallauria F, Grimaldi M, Oliva F, Senni M, Tondo C, Zecchin M, Cappannoli L, Giannotti Santoro M, Ziacchi M, Porcari A, and Sinagra G
- Subjects
- Humans, Registries, Stroke Volume, Treatment Outcome, Heart Failure therapy, Myocardial Contraction
- Abstract
This critical review illustrates the pathophysiological aspects and available scientific evidence about cardiac contractility modulation therapy. A useful algorithm dealing with the essential decisional knots to consider for device implantation in patients with heart failure in NYHA class >II and ejection fraction ≤45% is presented. The present review paves the way for the development of an Italian registry aiming at analyzing the characteristics of implanted patients based on a multiparametric approach, including cardiac biomarkers, to identify clinical profiles and predictors of response to therapy. The "Answers and Questions" section provides useful insights into pathophysiology, technical specifications, clinically relevant scenarios and future perspectives.
- Published
- 2021
- Full Text
- View/download PDF
10. [The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual report 2019].
- Author
-
Proclemer A, Zecchin M, Zanotto G, D'Onofrio A, De Ponti R, Pietro Riccicon la Collaborazione di Domenico Facchin R, Rebellato L, Ghidina M, Bianco G, Bernardelli E, Miconi A, Zorzin AF, and Gregori D
- Subjects
- Aged, Aged, 80 and over, Humans, Italy epidemiology, Registries, Atrial Fibrillation, Defibrillators, Implantable, Pacemaker, Artificial
- Abstract
Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2019 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers., Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards., Results: PM Registry: data about 22 889 PM implantations were collected (19 621 first implants and 3268 replacements). The number of collaborating centers was 173. Median age of treated patients was 81 years (75 quartile I; 87 quartile III). ECG indications included atrioventricular conduction disorders in 33.3% of first PM implants, sick sinus syndrome in 16.4%, atrial fibrillation plus bradycardia in 11.6%, other in 38.7%. Among atrioventricular conduction defects, third-degree atrioventricular block was the most common type (18.3% of first implants). Use of single-chamber PMs was reported in 25.5% of first implants, of dual-chamber PMs in 67.1%, of PMs with cardiac resynchronization therapy (CRT) in 1.5%, and of single lead atrial-synchronized ventricular stimulation (VDD/R PMs) in 5.8%. ICD Registry: data about 17 328 ICD implantations were collected (12 129 first implants and 5199 replacements). The number of collaborating centers was 425. Median age of treated patients was 71 years (62 quartile I; 77 quartile III). Primary prevention indication was reported in 83.1% of first implants, secondary prevention in 16.9% (cardiac arrest in 5.9%). A single-chamber ICD was used in 26.1% of first implants, dual-chamber ICD in 28.0% and biventricular ICD in 45.9%., Conclusions: The PM and ICD Registry appears fundamental for monitoring PM and ICD utilization on a large national scale with rigorous examination of demographics and clinical indications. The PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The use of CRT-PM regards a very limited number of patients. The ICD Registry documented a large use of prophylactic and biventricular ICD, reflecting a favorable adherence to trials and guidelines in clinical practice. In order to increase and optimize the cooperation of Italian implanting centers, online data entry (https://www.aiac.it/riprid) should be adopted at large scale.
- Published
- 2021
- Full Text
- View/download PDF
11. [Arrhythmias and sudden death in neuromuscular disorders].
- Author
-
Zecchin M, Calvanese R, Pignalberi C, Mascioli G, Bardari S, China P, Sgarito G, and Nesti M
- Subjects
- Arrhythmias, Cardiac genetics, Death, Sudden, Cardiac etiology, Electrocardiography, Humans, Cardiomyopathies genetics, Neuromuscular Diseases complications, Neuromuscular Diseases genetics
- Abstract
Neuromuscular diseases (NMD) are a broadly defined group of disorders that all involve injury or dysfunction of peripheral nerves, neuromuscular junction or muscle, often with dominant or recessive pattern of inheritance. Cardiac involvement is uncommon, in particular with cardiomyopathies and brady/tachyarrhythmias. The causes of cardiac involvement are unclear: replacement fibrosis, alteration of membrane permeability, sympathetic hyperactivity, or accumulation of toxic metabolites can play a role in the pathogenesis of cardiac disorders. The early diagnosis is of pivotal importance to prevent evolution of the disease: electrocardiographic alterations and arrhythmias, particularly if associated with family history for cardiomyopathy or sudden death, can be an early signal of cardiomyopathy associated with NMD. Genetic analysis can improve prognostic stratification, particularly related to arrhythmic risk, and guide to a tailored therapy.
- Published
- 2021
- Full Text
- View/download PDF
12. [ANMCO/SIC Consensus document on the management of myocarditis].
- Author
-
Cipriani M, Merlo M, Gabrielli D, Ammirati E, Autore C, Basso C, Caforio A, Caldarola P, Camici P, Di Lenarda A, Frustaci A, Imazio M, Oliva F, Pedrotti P, Perazzolo Marra M, Rapezzi C, Urbinati S, Zecchin M, Filardi PP, Colivicchi F, Indolfi C, Frigerio M, and Sinagra G
- Subjects
- Adolescent, Biopsy, Consensus, Female, Humans, Male, Stroke Volume, Ventricular Function, Left, Cardiology, Myocarditis diagnosis, Myocarditis etiology, Myocarditis therapy
- Abstract
Myocarditis is an inflammatory heart disease that can occur acutely, as in acute myocarditis, or persistently, as in chronic myocarditis or chronic inflammatory cardiomyopathy. Different agents can induce myocarditis, with viruses being the most common triggers. Generally, acute myocarditis affects relatively young people and men more than women. Myocarditis has a broad spectrum of clinical presentations and evolution trajectories, although most cases resolve spontaneously. Patients with reduced left ventricular ejection fraction, heart failure symptoms, advanced atrioventricular block, sustained ventricular arrhythmias or cardiogenic shock (the latter known as fulminant myocarditis) are at increased risk for death and heart transplantation. The presentation of chronic inflammatory cardiomyopathy may be more subtle, with progressive symptoms of heart failure or appearance of rhythm disturbance, not rarely preceded by an infective episode. Autoimmune disorder or systemic inflammatory conditions can be another significant predisposing substrate of myocarditis, especially in women. Emerging causes of myocarditis are drug-related like the new anticancer therapies, the immune checkpoint inhibitors. In this Italian Association of Hospital Cardiologists (ANMCO) and Italian Society of Cardiology (SIC) expert consensus document on myocarditis, we propose diagnostic strategies for identifying possible causes of the disease and factors associated with increased risk. Finally, we propose potential treatments and when referring patients to tertiary centers, especially for high-risk patients. Even if endomyocardial biopsy is the invasive diagnostic tool for making definitive diagnosis and differentiation of histological subtypes (i.e., lymphocytic vs eosinophilic vs giant cell myocarditis), it is not always readily available in all centers. Thus, we propose when this exam is mandatory or when it can be postponed or substituted by cardiac magnetic resonance imaging. This document reflects the Italian perspective on managing patients with myocarditis and their follow-up, considering also current US and European scientific position statements.
- Published
- 2020
- Full Text
- View/download PDF
13. [Diagnostic work-up and clinical management of cardiomyopathies: the operative protocol from the Cardiothoracovascular Department of Trieste, Italy].
- Author
-
Merlo M, Cappelletto C, De Angelis G, Porcari A, Caiffa T, Lardieri G, Pagnan L, Severini GM, Dal Ferro M, Stolfo D, Vitrella G, De Luca A, Korkova R, Massa L, Tavcˇar I, Aleksova A, Barbati G, Zanchi C, Ramani F, Di Lenarda A, Perkan A, Mestroni L, Zecchin M, Pinamonti B, Bussani R, and Sinagra G
- Subjects
- Adolescent, Arrhythmogenic Right Ventricular Dysplasia diagnosis, Arrhythmogenic Right Ventricular Dysplasia genetics, Arrhythmogenic Right Ventricular Dysplasia therapy, Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic diagnosis, Cardiomyopathy, Hypertrophic genetics, Cardiomyopathy, Hypertrophic therapy, Humans, Italy, Cardiomyopathies diagnosis, Cardiomyopathies therapy
- Abstract
Cardiomyopathies are primary myocardial disorders, genetically determined, with clinical onset between the third and the fifth decade of life. They represent the main causes of sudden cardiac death and heart failure in the youth. The more common myocardial diseases in clinical practice are dilated cardiomyopathy, arrhythmogenic cardiomyopathy and hypertrophic cardiomyopathy. Next generation sequencing techniques, recently available for genetics researches, together with the diffusion of advanced imaging techniques, permitted in the last years a deeper knowledge of these pathologies. Nevertheless, diagnosis, etiology and several aspects of patients' clinical management remain complex and controversial. This review paper aims to propose some operative flow-charts, derived from scientific evidences and the internal protocol of the Cardiothoracovascular Department of Trieste Hospital, Italian referral Center for cardiomyopathies and heart failure, with more than 30 years of experience in diagnosis and management of patients who suffer from primary myocardial disorders.
- Published
- 2020
- Full Text
- View/download PDF
14. [ANMCO Position paper: Guidance for the management of suspected or confirmed COVID-19 patients requiring urgent electrophysiological procedures].
- Author
-
Gulizia MM, Zecchin M, Colivicchi F, Francese GM, Murrone A, Caldarola P, Di Lenarda A, Valente S, Roncon L, Amodeo E, Aspromonte N, Cipriani MG, Domenicucci S, Imazio M, Scotto Di Uccio F, Urbinati S, and Gabrielli D
- Subjects
- Arrhythmias, Cardiac complications, Betacoronavirus, COVID-19, COVID-19 Testing, Clinical Laboratory Techniques, Electrophysiologic Techniques, Cardiac methods, Humans, Infection Control methods, Prosthesis Implantation methods, Risk Assessment, SARS-CoV-2, Arrhythmias, Cardiac therapy, Coronavirus Infections complications, Coronavirus Infections diagnosis, Coronavirus Infections prevention & control, Electrophysiologic Techniques, Cardiac standards, Infectious Disease Transmission, Patient-to-Professional prevention & control, Pacemaker, Artificial, Pandemics prevention & control, Personal Protective Equipment, Pneumonia, Viral complications, Pneumonia, Viral diagnosis, Pneumonia, Viral prevention & control
- Published
- 2020
- Full Text
- View/download PDF
15. [2019 ESC Guidelines on supraventricular tachycardias: what's new?]
- Author
-
Zecchin M and Bianco E
- Subjects
- Humans, Practice Guidelines as Topic, Tachycardia, Supraventricular therapy
- Published
- 2020
- Full Text
- View/download PDF
16. [The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual report 2018].
- Author
-
Proclemer A, Zecchin M, D'Onofrio A, Boriani G, Ricci RP, Rebellato L, Ghidina M, Bianco G, Bernardelli E, Miconi A, Zorzin AF, and Gregori D
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Arrhythmias, Cardiac physiopathology, Child, Electrocardiography, Female, Guideline Adherence, Humans, Italy, Male, Middle Aged, Practice Guidelines as Topic, Primary Prevention statistics & numerical data, Registries, Secondary Prevention statistics & numerical data, Young Adult, Arrhythmias, Cardiac therapy, Cardiac Resynchronization Therapy statistics & numerical data, Defibrillators, Implantable statistics & numerical data, Pacemaker, Artificial statistics & numerical data
- Abstract
Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2018 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers., Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards., Results: PM Registry: data about 23 912 PM implantations were collected (20 084 first implants and 3828 replacements). The number of collaborating centers was 180. Median age of treated patients was 81 years (75 quartile I; 86 quartile III). ECG indications included atrioventricular conduction disorders in 34.5% of first PM implants, sick sinus syndrome in 18.3%, atrial fibrillation plus bradycardia in 13.0%, other in 34.2%. Among atrioventricular conduction defects, third-degree atrioventricular block was the most common type (19.2% of first implants). Use of single-chamber PMs was reported in 24.9% of first implants, of dual-chamber PMs in 67.6%, of PMs with cardiac resynchronization therapy (CRT) in 1.6%, and of single lead atrial-synchronized ventricular stimulation (VDD/R PMs) in 5.9%. ICD Registry: data about 18 353 ICD implantations were collected (13 944 first implants and 4359 replacements). The number of collaborating centers was 433. Median age of treated patients was 71 years (63 quartile I; 78 quartile III). Primary prevention indication was reported in 84.3% of first implants, secondary prevention in 15.7% (cardiac arrest in 5.3%). A single-chamber ICD was used in 27.9% of first implants, dual-chamber ICD in 31.9% and biventricular ICD in 40.2%., Conclusions: The PM and ICD Registry appears fundamental for monitoring PM and ICD utilization on a large national scale with rigorous examination of demographics and clinical indications. The PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The use of CRT-PM regards a very limited number of patients. The ICD Registry documented a large use of prophylactic and biventricular ICD, reflecting a favorable adherence to trials and guidelines in clinical practice. In order to increase and optimize the cooperation of Italian implanting centers, online data entry (http://www.aiac.it/riprid) should be adopted at large scale.
- Published
- 2020
- Full Text
- View/download PDF
17. [Cardiological counseling and perioperative management of heart disease patients. Protocol of the University of Trieste - Year 2019].
- Author
-
Massa L, Mascaretti LG, Ratti C, Zecchin M, Perkan A, Fabris E, Vitrella G, Fabro M, Luzzati R, Di Lenarda A, Pelusi L, Bergamini PR, and Sinagra G
- Subjects
- Cardiology methods, Heart Diseases physiopathology, Humans, Italy, Risk, Time Factors, Cardiac Surgical Procedures methods, Heart Diseases surgery, Perioperative Care methods
- Abstract
The management of patients with heart disease or suspected heart disease, who are hospitalized and/or who should undergo surgery or an invasive procedure, is very complex for the comorbidities often present, the multiple therapies taken and the frequent presence of advanced cardiac devices.The purpose of this document is to provide indications and standardize the behavior of different clinicians in the management of heart disease patients or those with suspected heart disease in order (i) to manage acute cardiac conditions with appropriate timing and accuracy, and (ii) to define the cardiovascular risk in the individual patient with appropriate timing and indications, allowing patients to face any surgery or invasive procedure with the lowest risk correlated to his heart disease.
- Published
- 2019
- Full Text
- View/download PDF
18. [The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual report 2017].
- Author
-
Proclemer A, Zecchin M, D'Onofrio A, Ricci RP, Boriani G, Rebellato L, Ghidina M, Bianco G, Bernardelli E, Miconi A, Zorzin AF, and Gregori D
- Subjects
- Aged, Aged, 80 and over, Arrhythmias, Cardiac epidemiology, Arrhythmias, Cardiac physiopathology, Electrocardiography, Female, Humans, Italy, Male, Middle Aged, Primary Prevention statistics & numerical data, Registries, Secondary Prevention statistics & numerical data, Surveys and Questionnaires, Arrhythmias, Cardiac therapy, Cardiac Resynchronization Therapy statistics & numerical data, Defibrillators, Implantable statistics & numerical data, Pacemaker, Artificial statistics & numerical data
- Abstract
Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2017 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers., Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards., Results: PM Registry: data about 23 457 PM implantations were collected (19 378 first implant and 4079 replacements). The number of collaborating centers was 185. Median age of treated patients was 81 years (75 quartile I; 86 quartile III). ECG indications included atrioventricular conduction disorders in 37.1% of first PM implants, sick sinus syndrome in 19.5%, atrial fibrillation plus bradycardia in 13.2%, other in 30.2%. Among atrioventricular conduction defects, third-degree atrioventricular block was the most common type (21.0% of first implants). Use of single-chamber PMs was reported in 25.6% of first implants, of dual-chamber PMs in 66.7%, of PMs with cardiac resynchronization therapy (CRT) in 1.4%, and of single lead atrial-synchronized ventricular stimulation (VDD/R PMs) in 6.3%. ICD Registry: data about 19 023 ICD implantations were collected (13 898 first implants and 5125 replacements). The number of collaborating centers was 437. Median age of treated patients was 71 years (63 quartile I; 78 quartile III). Primary prevention indication was reported in 81.8% of first implants, secondary prevention in 18.2% (cardiac arrest in 6.4%). A single-chamber ICD was used in 27.0% of first implants, dual-chamber in 33.6% and biventricular in 39.3%., Conclusions: The PM and ICD Registry appears fundamental for monitoring PM and ICD utilization on a large national scale with rigorous examination of demographics and clinical indications. The PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The use of CRT-PM regards a very limited number of patients. The ICD Registry documented a large use of prophylactic and biventricular ICD, reflecting a favorable adherence to trials and guidelines in clinical practice. In order to increase and optimize the cooperation of Italian implanting centers, online data entry (http://www.aiac.it/riprid) should be adopted at large scale.
- Published
- 2019
- Full Text
- View/download PDF
19. [The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual report 2016].
- Author
-
Proclemer A, Zecchin M, D'Onofrio A, Boriani G, Facchin D, Rebellato L, Ghidina M, Bianco G, Bernardelli E, Pucher E, and Gregori D
- Subjects
- Aged, Aged, 80 and over, Arrhythmias, Cardiac epidemiology, Arrhythmias, Cardiac physiopathology, Electrocardiography, Female, Humans, Italy, Male, Middle Aged, Primary Prevention statistics & numerical data, Registries, Secondary Prevention statistics & numerical data, Societies, Medical, Arrhythmias, Cardiac therapy, Cardiac Resynchronization Therapy statistics & numerical data, Defibrillators, Implantable statistics & numerical data, Pacemaker, Artificial statistics & numerical data
- Abstract
Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2016 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers., Methods: The registry collects prospectively national PM and ICD implantation activity on the basis of European cards., Results: PM Registry: data about 23 496 PM implantations were collected (19 003 first implant and 4493 replacements). The number of collaborating centers was 204. Median age of treated patients was 81 years (75 quartile I; 86 quartile III). ECG indications included atrioventricular conduction disorders in 39.8% of first PM implants, sick sinus syndrome in 22.1%, atrial fibrillation plus bradycardia in 14.1%, other in 24.0%. Among atrioventricular conduction defects, third-degree atrioventricular block was the most common type (22.18% of first implants). Use of single-chamber PMs was reported in 26.9% of first implants, of dual-chamber PMs in 65.0%, of PMs with cardiac resynchronization therapy (CRT) in 1.5%, and of single lead atrial-synchronized ventricular stimulation (VDD/R PMs) in 6.6%. ICD Registry: data about 20 350 ICD implantations were collected (14 763 first implants and 5587 replacements). The number of collaborating centers was 430. Median age of treated patients was 72 years (63 quartile I; 78 quartile III]. Primary prevention indication was reported in 79.0% of first implants, secondary prevention in 21.0% (cardiac arrest in 7.9%). A single-chamber ICD was used in 32.2% of first implants, dual-chamber in 31.1% and biventricular in 36.7%., Conclusions: The PM and ICD Registry appears fundamental for monitoring PM and ICD utilization on a large national scale with rigorous examination of demographics and clinical indications. The PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The use of CRT-PM regards a very limited number of patients. The ICD Registry documented a large use of prophylactic and biventricular ICD, reflecting a favorable adherence to trials and guidelines in clinical practice.
- Published
- 2018
- Full Text
- View/download PDF
20. [The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual report 2015].
- Author
-
Proclemer A, Zecchin M, D'Onofrio A, Boriani G, Botto GL, Facchin D, Rebellato L, Ghidina M, Bianco G, Bernardelli E, Pucher E, and Gregori D
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Arrhythmias, Cardiac physiopathology, Child, Female, Humans, Italy, Male, Middle Aged, Registries, Risk Factors, Societies, Medical, Surveys and Questionnaires, Time Factors, Treatment Outcome, Arrhythmias, Cardiac therapy, Cardiology, Defibrillators, Implantable statistics & numerical data, Guideline Adherence, Pacemaker, Artificial statistics & numerical data, Patient Selection
- Abstract
Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2015 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers., Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards., Results: PM Registry: data about 24 285 PM implantations were collected (19 194 first implant and 5091 replacements). The number of collaborating centers was 218. Median age of treated patients was 81 years (75 quartile I; 86 quartile III). ECG indications included atrioventricular conduction disorders in 42.8% of first PM implants, sick sinus syndrome in 22.9%, atrial fibrillation plus bradycardia in 15.1%, other in 19.2%. Among atrioventricular conduction defects, third-degree atrioventricular block was the most common type (23.8% of first implants). Use of single-chamber PMs was reported in 26.9% of first implants, of dual-chamber PMs in 63.4%, of PMs with cardiac resynchronization therapy (CRT) in 1.8%, and of single lead atrial-synchronized ventricular stimulation (VDD/R PMs) in 7.9%. ICD Registry: data about 15 363 ICD implantations were collected (11 453 first implants and 3910 replacements). The number of collaborating centers was 434. Median age of treated patients was 71 years (63 quartile I; 78 quartile III]. Primary prevention indication was reported in 77.3% of first implants, secondary prevention in 22.7% (cardiac arrest in 8.0%). A single-chamber ICD was used in 29.3% of first implants, dual-chamber in 34.6% and biventricular in 36.1%., Conclusions: The PM and ICD Registry appears fundamental for monitoring PM and ICD utilization on a large national scale with rigorous examination of demographics and clinical indications. The PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The use of CRT-PM regards a very limited number of patients. The ICD Registry documented a large use of prophylactic and biventricular ICD, reflecting a favorable adherence to trials and guidelines in clinical practice.
- Published
- 2017
- Full Text
- View/download PDF
21. [The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing--Annual report 2014].
- Author
-
Proclemer A, Zecchin M, D'Onofrio A, Botto GL, Facchin D, Rebellato L, Ghidina M, Bianco G, Bernardelli E, Pucher E, and Gregori D
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Cardiology, Child, Female, Humans, Italy, Male, Middle Aged, Societies, Medical, Young Adult, Defibrillators, Implantable statistics & numerical data, Pacemaker, Artificial statistics & numerical data, Registries
- Abstract
Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2014 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers., Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards., Results: PM Registry: data about 24 680 PM implantations were collected (19 480 first implant and 5200 replacements). The number of collaborating centers was 208. Median age of treated patients was 81 years (75 quartile I; 86 quartile III). ECG indications included atrioventricular conduction disorders in 45.3% of first PM implants, sick sinus syndrome in 23.1%, atrial fibrillation plus bradycardia in 11.7%, other in 19.9%. Among atrioventricular conduction defects, third-degree atrioventricular block was the most common type (22.7% of first implants). Use of single-chamber PMs was reported in 26.9% of first implants, of dual-chamber PMs in 63.6%, of PMs with cardiac resynchronization therapy (CRT) in 1.7%, and of single lead atrial-synchronized ventricular stimulation (VDD/R PMs) in 7.8%. ICD Registry: data about 17 116 ICD implantations were collected (11 274 first implants and 5842 replacements). The number of collaborating centers was 424. Median age of treated patients was 71 years (62 quartile I; 77 quartile III). Primary prevention indication was reported in 72.3% of first implants, secondary prevention in 27.7% (cardiac arrest in 10.1%). A single-chamber ICD was used in 32.2% of first implants, dual-chamber in 37.1% and biventricular in 30.7%., Conclusions: The PM and ICD Registry appears fundamental for monitoring PM and ICD utilization on a large national scale with rigorous examination of demographics and clinical indications. The PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The use of CRT-PM regards a very limited number of patients. The ICD Registry documented a large use of prophylactic and biventricular ICD, reflecting a favorable adherence to trials and guidelines in clinical practice.
- Published
- 2016
- Full Text
- View/download PDF
22. [Dilated cardiomyopathy: a dynamic disease - clinical course, reverse remodeling and prognostic stratification].
- Author
-
Merlo M, Gigli M, Poli S, Stolfo D, Brun F, Lardieri G, Pinamonti B, Zecchin M, Pivetta A, Vitrella G, Di Lenarda A, and Sinagra G
- Subjects
- Cardiomyopathy, Dilated genetics, Cardiomyopathy, Dilated physiopathology, Cardiomyopathy, Dilated therapy, Disease Progression, Early Diagnosis, Follow-Up Studies, Humans, Incidence, Italy epidemiology, Mass Screening, Predictive Value of Tests, Prevalence, Prognosis, Sensitivity and Specificity, Severity of Illness Index, Cardiomyopathy, Dilated diagnosis, Cardiomyopathy, Dilated epidemiology, Magnetic Resonance Imaging, Ventricular Remodeling
- Abstract
Dilated cardiomyopathy (DCM) is a relatively rare primary heart muscle disease with genetic or post-inflammatory etiology. In the last decade, the incidence and prevalence of the disease have significantly increased as a consequence of an earlier diagnosis supported by extensive familial screening programs and by the improvement in diagnostic techniques. Moreover, current therapeutic strategies have deeply modified the prognosis of DCM with a dramatic reduction in mortality. A significant number of patients with DCM present an impressive response to pharmacological and non-pharmacological therapy in terms of left ventricular reverse remodeling (reduction in ventricular size with improvement of systolic function), which confers a more favorable prognosis in the long term. However, the identification of patients with an increased likelihood of improvement after therapeutic optimization remains a challenging issue; in particular the assessment of arrhythmic risk carries important implications. Finally, the long-term follow-up of patients showing a significant left ventricular functional recovery under optimal treatment is still poorly known. Hence, the aim of the present review is to provide an insight into the clinical evolution/long-term follow-up of DCM, which should be actually considered a dynamic process rather than a static and chronic disease. Left ventricular reverse remodeling should be considered a key therapeutic goal, mostly associated with a long-standing recovery, but cannot be considered the expression of permanent "healing", confirming the need for a systematic and careful follow-up over time in this setting.
- Published
- 2016
- Full Text
- View/download PDF
23. [Nonvalvular atrial fibrillation: data from the Observatory of Cardiovascular Diseases in the province of Trieste (Italy)].
- Author
-
Mazzone C, Carriere C, Grande E, Iorio AM, Barbati G, Zecchin M, Serdoz LV, Cioffi G, Tarantini L, Sinagra G, Scardi S, and Di Lenarda A
- Subjects
- Anticoagulants adverse effects, Anticoagulants therapeutic use, Atrial Fibrillation complications, Atrial Fibrillation therapy, Cause of Death, Factor Xa Inhibitors adverse effects, Factor Xa Inhibitors therapeutic use, Female, Hemorrhage chemically induced, Hemorrhage epidemiology, Hospitalization statistics & numerical data, Humans, Incidence, Italy epidemiology, Male, Metabolic Syndrome epidemiology, Prevalence, Prognosis, Prospective Studies, Registries, Risk Factors, Severity of Illness Index, Stroke epidemiology, Stroke etiology, Stroke prevention & control, Thromboembolism epidemiology, Thromboembolism etiology, Thromboembolism prevention & control, Thrombophilia drug therapy, Treatment Outcome, Atrial Fibrillation epidemiology
- Abstract
Background: Nonvalvular atrial fibrillation (NVAF) is the most common arrhythmia in outpatients and is associated with increased mortality, thromboembolic and hemorrhagic events. Although several international studies have evaluated its prognostic impact in the real world, Italian data are still lacking. Our aim was to define the prevalence, comorbidity, treatment and outcome in a population of "real-life" outpatients with NVAF., Methods: From 2009 to 2013, 21 282 consecutive patients referred to the Cardiovascular Center of Trieste were enrolled in the study. NVAF was defined in the absence of moderate-to-severe valvular disease, valvular interventions, rheumatic heart disease. Events evaluated in the follow-up included mortality, hospitalizations, thromboembolism and hemorrhage. Clinical data and events were derived from the cardiac regional electronic patient records and the ICD-9 hospital discharge records., Results: 3379 patients (15.8%) had NVAF (35.6% paroxysmal, 34.5% persistent, 29.9% permanent); compared to the general population these patients were older, predominantly male, with hypertension, diabetes and history of stroke/transient ischemic attack and heart failure. Oral anticoagulant therapy was prescribed in 54% of cases, above all in persistent or permanent forms, in patients with higher CHA2DS2-VASc score and younger age. The rate of all-cause mortality, cardiovascular hospitalization, thromboembolic and hemorrhagic events during follow-up was higher in patients with NVAF than in the general population. The use of oral anticoagulant therapy reduced the incidence of thromboembolic events. CHA2DS2-VASc score emerged as an independent predictor of thromboembolic events in patients with paroxysmal (35% higher risk), persistent (40% higher risk) and permanent atrial fibrillation (34% higher risk than patients without atrial fibrillation)., Conclusions: In "real-life" outpatients NVAF is associated with older age, more comorbidities and increased cardiovascular events. CHA2DS2-VASc and HAS-BLED scores predict accurately the risk for thromboembolic and hemorrhagic events. Oral anticoagulation reduces thromboembolic events, but its use is limited to just half of the patients.
- Published
- 2015
- Full Text
- View/download PDF
24. [Author reply].
- Author
-
Berti S, Themistoclakis S, Santoro G, De Ponti R, Danna P, Zecchin M, Bedogni F, and Padeletti L
- Subjects
- Humans, Atrial Appendage surgery, Atrial Fibrillation therapy, Septal Occluder Device, Stroke prevention & control
- Published
- 2015
25. [The pacemaker and implantable cardioverter-defibrillator registry of the Italian Association Arrhythmology Cardiac Pacing and cardiac pacing - annual report 2013].
- Author
-
Proclemer A, Zecchin M, D'Onofrio A, Botto GL, Rebellato L, Ghidina M, Bianco G, Bernardelli E, Pucher E, and Gregori D
- Subjects
- Aged, Aged, 80 and over, Arrhythmias, Cardiac physiopathology, Cooperative Behavior, Guideline Adherence, Humans, Italy, Middle Aged, Practice Guidelines as Topic, Registries, Societies, Medical, Arrhythmias, Cardiac therapy, Defibrillators, Implantable statistics & numerical data, Pacemaker, Artificial statistics & numerical data
- Abstract
Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2013 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers., Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards., Results: PM Registry: data about 25 419 PM implantations were collected (19 134 first implant and 6285 replacements). The number of collaborating centers was 275. Median age of treated patients was 80 years (74 quartile I; 86 quartile III). ECG indications included atrioventricular conduction disorders in 43.6% of first PM implants, sick sinus syndrome in 24.7%, atrial fibrillation plus bradycardia in 12.9%, other in 18.8%. Among atrioventricular conduction defects, third-degree atrioventricular block was the most common type (23.2% of first implants). Use of single-chamber PMs was reported in 27.2% of first implants, of dual-chamber PMs in 62.6%, of PMs with cardiac resynchronization therapy (CRT) in 1.8%, and of single lead atrial-synchronized ventricular stimulation (VDD/R PMs) in 8.4%. ICD Registry: data about 16 519 ICD implantations were collected (11 474 first implants and 5045 replacements). The number of collaborating centers was 430. Median age of treated patients was 71 years (63 quartile I; 77 quartile III). Primary prevention indication was reported in 76% of first implants, secondary prevention in 24.0% (cardiac arrest in 7.8%). A single-chamber ICD was used in 27.2% of first implants, dual-chamber in 35.9% and biventricular in 36.8%., Conclusions: The PM and ICD Registry appears fundamental for monitoring PM and ICD utilization on a large national scale with rigorous examination of demographics and clinical indications. The PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The use of CRT-PM regards a very limited number of patients. The ICD Registry documented a constant increase in prophylactic and biventricular ICD use, reflecting a favorable adherence to trials and guidelines in clinical practice.
- Published
- 2014
- Full Text
- View/download PDF
26. [GISE/AIAC position paper on percutaneous left atrial appendage occlusion in patients with nonvalvular atrial fibrillation: recommendations for patient selection, facilities, competences, organizing and training requirements].
- Author
-
Berti S, Themistoclakis S, Santoro G, De Ponti R, Danna P, Zecchin M, Bedogni F, and Padeletti L
- Subjects
- Anticoagulants therapeutic use, Atrial Fibrillation complications, Clinical Competence, Humans, Italy, Patient Care Team organization & administration, Patient Selection, Atrial Appendage surgery, Atrial Fibrillation therapy, Septal Occluder Device, Stroke prevention & control
- Abstract
Thromboembolism from the left atrial appendage is the most feared complication in patients with atrial fibrillation (AF). The cornerstone for the management of chronic nonvalvular AF is stroke reduction with oral anticoagulation (OAC). However, poor compliance, maintaining a narrow therapeutic window, and major side effects such as bleeding have severely limited its use, creating a therapeutic dilemma. About 20% of AF patients do not receive OAC due to contraindications and less than half of AF patients are not on OAC due to reluctance of the prescribing physician and/or patient non-compliance. Fortunately, over the past decade, the introduction of percutaneous approaches for left atrial appendage occlusion has offered a viable alternative to the management of nonvalvular AF in patients with OAC contraindication. Occlusion devices such as the Amplatzer Cardiac Plug and Watch man device have shown their noninferiority to OAC for stroke prophylaxis with less bleeding complications, while more recently some new devices have been introduced. The aim of this position paper is to review the most relevant clinical aspects of left atrial appendage occlusion from patient selection to periprocedural and follow-up management. In addition, the importance of a medical team and an organizational environment adequate to optimize all the steps of this procedure is discussed.
- Published
- 2014
- Full Text
- View/download PDF
27. [The pacemaker and implantable cardioverter-defibrillator registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual Report 2012].
- Author
-
Proclemer A, Zecchin M, Lunati M, Rebellato L, Ghidina M, Bianco G, Bernardelli E, Pucher E, and Gregori D
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Humans, Italy, Male, Middle Aged, Societies, Medical, Young Adult, Defibrillators, Implantable statistics & numerical data, Pacemaker, Artificial statistics & numerical data, Registries
- Abstract
Background: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2012 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers., Methods: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards., Results: PM Registry: data about 25 611 PM implantations were collected (18 870 first implant and 6741 replacements). The number of collaborating centers was 245. Median age of treated patients was 80 years (74 quartile I; 86 quartile III). ECG indications included atrioventricular conduction disorders in 41.9% of first PM implants, sick sinus syndrome in 26.0%, atrial fibrillation plus bradycardia in 13.7%, other in 18.4%. Among atrioventricular conduction defects, third-degree atrioventricular block was the most common type (21.7% of first implants). Use of single-chamber PMs was reported in 29.0% of first implants, of dual-chamber PMs in 61.3%, of PMs with cardiac resynchronization therapy (CRT) in 1.7%, and of single lead atrial-synchronized ventricular stimulation (VDD/R PMs) in 8.0%. ICD REGISTRY: data about 16 606 ICD implantations were collected (11 393 first implants and 5213 replacements). The number of collaborating centers was 427. Median age of treated patients was 71 years (62 quartile I; 77 quartile III). Primary prevention indication was reported in 68.6% of first implants, secondary prevention in 31.4% (cardiac arrest in 9.0%). A single-chamber ICD was used in 29.4% of first implants, dual-chamber in 37.6% and biventricular in 32.9%., Conclusions: The PM and ICD Registry appears fundamental for monitoring PM and ICD utilization on a large national scale with rigorous examination of demographics and clinical indications. The PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The use of CRT-PM regards a very limited number of patients. The ICD Registry documented a constant increase in prophylactic and biventricular ICD use, reflecting a favorable adherence to trials and guidelines in clinical practice.
- Published
- 2013
- Full Text
- View/download PDF
28. [Remarks on the guideline recommendations for cardioverter-defibrillator implantation for primary prevention of sudden cardiac Death in patients with severe ventricular dysfunction. Consensus Document of the Italian Association of Hospital Cardiologists (ANMCO)/Italian Society of Cardiology (SIC)/Italian Association of Arrhythmology and Cardiac Pacing (AIAC)].
- Author
-
Berisso MZ, Bongiorni MG, Curnis A, Calvi V, Catanzariti D, Gaita F, Gulizia MM, Inama G, Landolina ME, La Rovere MT, Mantovan R, Mascioli G, Occhetta E, Padeletti L, Salerno-Uriarte JA, Santini M, Sassone B, Senni M, and Zecchin M
- Subjects
- Humans, Prognosis, Risk Assessment, Severity of Illness Index, Death, Sudden, Cardiac etiology, Death, Sudden, Cardiac prevention & control, Defibrillators, Implantable adverse effects, Defibrillators, Implantable economics, Defibrillators, Implantable ethics, Practice Guidelines as Topic, Primary Prevention, Ventricular Dysfunction complications
- Abstract
The indications for implantable cardioverter-defibrillator (ICD) therapy for the prevention of sudden cardiac death in patients with severe left ventricular dysfunction have rapidly expanded over the last 10 years on the basis of the very satisfying results of the numerous randomized clinical trials that have provided the framework for guidelines. However, the analysis of clinical practice in the real world has highlighted some important criticisms in the complex process of selection-management of those patients candidates for ICD therapy: 1) approximately one fourth of all ICD implantations is not justified by clinical evidence, 2) approximately one half of patients with an indication for ICD therapy do not undergo implantation, 3) the benefits from ICD therapy do not apply uniformly to all patients, 4) the relationship between the lifesaving benefit and the potential for harm of ICD therapy is still scarcely known. The main reason for this clinical scenario can be ascribed to the guideline recommendations that are based only on few standard cut-off criteria and therefore too generic and insufficiently detailed. This does not help cardiologists in their decision-making process, and results in fear, uncertainty, and sometimes emotional choices. The aim of this consensus document is to discuss current guideline recommendations and to provide the Italian cardiologists with the most updated information to optimize the selection of patients with severe left ventricular dysfunction who should receive ICD therapy.
- Published
- 2013
- Full Text
- View/download PDF
29. [Sudden cardiac death in patients with left ventricular dysfunction from ischemic heart disease: role of the implantable defibrillator. Evidence, guidelines and good clinical judgment].
- Author
-
Serdoz LV, Fabris E, Lutman C, Merlo M, Zecchin M, and Sinagra G
- Subjects
- Evidence-Based Medicine, Humans, Practice Guidelines as Topic, Death, Sudden, Cardiac etiology, Death, Sudden, Cardiac prevention & control, Defibrillators, Implantable, Myocardial Ischemia complications, Ventricular Dysfunction, Left complications
- Abstract
A number of studies have shown that the implantable cardioverter-defibrillator (ICD) is the most effective therapy for the prevention of sudden cardiac death from ventricular arrhythmias in patients with ischemic heart disease and severe left ventricular dysfunction. However, ejection fraction should not be considered the only parameter for the identification of candidates to ICD; this may lead to a "hyper-simplification" of the choices and to often unnecessary or inappropriate implantations. The purpose of this paper was to review the literature data regarding indications for ICD implantation in primary prevention in patients with severe ischemic left ventricular dysfunction by taking into account different clinical settings, in particular the biological age, the comorbidity profile, the temporal length between the ischemic event and ICD implantation, the possible impact of revascularization in reducing the arrhythmic risk.
- Published
- 2012
- Full Text
- View/download PDF
30. [Indications for cardiology consultation and management of cardiac patients who will undergo surgical or endoscopic procedures: the proposal of the University Hospital of Trieste, Italy].
- Author
-
Massa L, Vitrella G, Zecchin M, Berlot G, Bergamini PR, Pelusi L, Lattuada L, and Sinagra G
- Subjects
- Anti-Bacterial Agents therapeutic use, Anticoagulants therapeutic use, Drug Therapy, Combination, Endocarditis, Bacterial prevention & control, Heart Diseases diagnosis, Hospitals, University, Humans, Italy, Platelet Aggregation Inhibitors therapeutic use, Preoperative Care, Quality of Health Care, Risk Assessment, Risk Factors, Treatment Outcome, Cardiac Surgical Procedures, Cardiology, Endoscopy, Heart Diseases therapy, Referral and Consultation
- Abstract
The number of patients affected by cardiovascular disease admitted to internal medicine and geriatric wards is expanding due to the increasing prevalence of cardiovascular disease in the ageing population. This contributes to a growing demand for cardiology consult visits, with requests for perioperative risk stratification for non-cardiac surgery or endoscopy, and general clinical management. This document was jointly drafted by the Cardiology and Anesthesiology departments, medical and surgical departments, and endoscopy services of the Azienda Ospedaliero-Universitaria "Ospedali Riuniti" in Trieste (Italy). It addresses critical issues such as antiplatelet and anticoagulant therapy in non-cardiac surgery, electric device management, and prophylaxis of bacterial endocarditis. It provides general guidelines and appropriateness criteria, prompted by the Joint Commission International and approved by the Hospital Guidelines Committee. It provides a basis for periodic educational meetings, and will be periodically updated. Periodic audits will monitor its application, and critical and controversial points, in order to promote quality of health care, organizational efficiency, and appropriateness.
- Published
- 2010
31. [Triple/quadruple therapy in heart failure: integrating scientific evidence with clinical reasoning].
- Author
-
Sinagra G, Sabbadini G, Zecchin M, and Di Lenarda A
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Angiotensin II Type 1 Receptor Blockers therapeutic use, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Cardiotonic Agents therapeutic use, Digoxin therapeutic use, Diuretics therapeutic use, Drug Therapy, Combination, Evidence-Based Medicine, Humans, Mineralocorticoid Receptor Antagonists therapeutic use, Treatment Outcome, Heart Failure drug therapy
- Abstract
Anti-neurohormonal pharmacological agents successfully tested in randomized controlled trials over the last two decades - firstly angiotensin-converting enzyme inhibitors (ACE-I), then beta-blockers (BB) and more recently aldosterone receptor-antagonists (ARA) and angiotensin II receptor blockers (ARB) - have significantly contributed to increase the chance of favorable outcomes in patients with chronic heart failure. An ACE-I and a BB, usually combined with diuretics and often with digoxin, continue to represent the cornerstones for the treatment of heart failure; moreover, most patients who are taking these drugs are now expected to receive as add-on therapies also an ARA and/or an ARB. However, as the number of available drugs increases coupled with the hope of greater clinical benefits, these more complicated pharmacological options are destined to generate even more controversy. Now, much debate is over to which triple (ACE-I + BB + ARA or ARB) and quadruple (ACE-I + BB + ARA + ARB) therapies may be offered. Current guidelines do not fully address the aim of providing straightforward guidance about what should be the third drug of the triple therapy and as to whether or not quadruple therapy may have any role in the present-day heart failure management. Adapting any pharmacological strategy--based upon both scientific evidence and clinical reasoning--to the specific profile of the individual patient can be helpful to circumvent uncertainties and errors in daily practice of medicine and make the best use of currently available drugs.
- Published
- 2007
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.