1. Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring
- Author
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Giovanni Vitale, Leo J. Hofland, Joseph A M J L Janssen, Claudio Franceschi, Giulia Ogliari, Letizia Maria Fatti, Davide Castaldi, Daniela Monti, Daniela Mari, Francesco Cavagnini, Elisa Cevenini, Laura Bucci, Steven W. J. Lamberts, Aimee J. Varewijck, Michael P. Brugts, and Internal Medicine
- Subjects
Male ,Aging ,medicine.medical_specialty ,Offspring ,Health Status ,media_common.quotation_subject ,medicine.medical_treatment ,Longevity ,Serum insulin ,030209 endocrinology & metabolism ,03 medical and health sciences ,0302 clinical medicine ,centenarians’ offspring ,Internal medicine ,medicine ,Humans ,IGF-I receptors ,Insulin-Like Growth Factor I ,Aged ,030304 developmental biology ,media_common ,Aged, 80 and over ,0303 health sciences ,biology ,Insulin ,Insulin sensitivity ,Cell Biology ,Pedigree ,Insulin receptor ,Endocrinology ,Human longevity ,IGF-I bioactivity ,biology.protein ,Adult Children ,insulin receptors ,Female ,centenarians ,Receptor activation ,Research Paper - Abstract
Centenarians' offspring represent a suitable model to study age-dependent variables (e. g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians' offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians' offspring. IGF-I bioactivity (p
- Published
- 2012